Fadahunsi H O, Coker A O, Usoro P D
Ann Trop Paediatr. 1987 Mar;7(1):54-8. doi: 10.1080/02724936.1987.11748474.
Ninety-two children with rheumatic heart disease were studied clinically, and through a post-diagnosis surveillance period of varying duration over a 10-year period. The logistics and effectiveness of secondary penicillin prophylaxis, administered monthly, were assessed during the surveillance period. Eighty-one (88%) of the 92 children were seen for the first time with already established rheumatic heart disease. Mitral insufficiency was the major functional defect in these children whose mean age was 8.6 years. There was a high default rate of just under 50% among children referred to the surveillance clinic. Socio-economic inadequacies were found to be major factors in the high default rate. Regular monthly parenteral penicillin was found to be effective in reducing recurrence of rheumatic fever and maintaining good health in these children.
对92名风湿性心脏病患儿进行了为期10年的临床研究，并在确诊后的不同时间段进行了随访监测。在监测期间，评估了每月进行的二级青霉素预防的可行性和有效性。92名患儿中有81名（88%）首次就诊时已患有风湿性心脏病。二尖瓣关闭不全是这些平均年龄为8.6岁患儿的主要功能缺陷。转诊至监测诊所的患儿中，未按时就诊率高达近50%。社会经济条件不足被认为是导致高未按时就诊率的主要因素。研究发现，每月定期注射青霉素对于降低这些患儿风湿热的复发率和保持健康状况是有效的。
