Hozumi M
Gan To Kagaku Ryoho. 1987 May;14(5 Pt 2):1349-57.
Recently, it has been shown clearly that various tumor cells can be induced by differentiation inducers including biological response modifiers, synthetic chemicals and conventional anticancer drugs to differentiate terminally both in vitro and in vivo into cells with normal characteristics. On differentiation, the cells cease to proliferate and lose their transplantability in either nude mice or syngeneic animals. Furthermore, prolongation by the differentiation inducers of survival times of animals inoculated with various tumors was confirmed. These findings suggest that induction of terminal cell differentiation by differentiation inducers is another approach to tumor therapy, that is "differentiation therapy" of tumors. In this review, recent results of basic and clinical studies on the differentiation therapy of tumors are described. The problems and perspectives of differentiation therapy are also discussed.
最近，已经清楚地表明，包括生物反应调节剂、合成化学物质和传统抗癌药物在内的各种分化诱导剂能够在体外和体内诱导各种肿瘤细胞终末分化为具有正常特征的细胞。分化时，细胞停止增殖，并在裸鼠或同基因动物中失去其移植能力。此外，还证实了分化诱导剂可延长接种各种肿瘤的动物的存活时间。这些发现表明，通过分化诱导剂诱导细胞终末分化是肿瘤治疗的另一种方法，即肿瘤的“分化疗法”。在这篇综述中，描述了肿瘤分化疗法的基础和临床研究的最新结果。还讨论了分化疗法的问题和前景。
