Uchida M, Kaneko S, Inoue A
Gan To Kagaku Ryoho. 1987 Jun;14(6 Pt 1):1781-8.
Fifty-three patients with postoperative recurrent epidermoid carcinomas of the head and neck were treated with BEAM, DP, MBD and CAP regimens. Complete response (CR) and partial response (PR) were achieved in 9% and 23% of all evaluable patients, respectively. Especially, in patients with oral cancer (17 cases), the response rate was only 23% (CR 0%, PR 23%). From our results, it was concluded that chemotherapy in any form must be palliative for a patient who has received prior unsuccessful radiotherapy or surgery. For previously untreated patients who present with Stage III or IV advanced carcinoma, combination chemotherapy with CDDP, MTX and PEP should be considered as the initial method of treatment. Adjuvant chemotherapy and intra-arterial chemotherapy for oral cancer should also be considered. Adjuvant chemotherapy combined with UFT and MTX is indicted to be effective for the prevention of local recurrence and micrometastases, but a further randomized study is necessary to confirm these findings.
53例头颈部术后复发性表皮样癌患者接受了BEAM、DP、MBD和CAP方案治疗。在所有可评估患者中，完全缓解（CR）和部分缓解（PR）分别为9%和23%。特别是口腔癌患者（17例），缓解率仅为23%（CR 0%，PR 23%）。根据我们的结果得出结论，对于先前接受放疗或手术未成功的患者，任何形式的化疗都必须是姑息性的。对于初诊为Ⅲ期或Ⅳ期晚期癌的未治疗患者，应考虑顺铂、甲氨蝶呤和PEP联合化疗作为初始治疗方法。口腔癌的辅助化疗和动脉内化疗也应予以考虑。辅助化疗联合优福定和甲氨蝶呤被认为对预防局部复发和微转移有效，但需要进一步的随机研究来证实这些发现。
