Price M L, Jones E W, MacDonald D M
Br J Dermatol. 1987 May;116(5):681-91. doi: 10.1111/j.1365-2133.1987.tb05902.x.
The clinical and histopathological features of 12 female patients with Flegel's disease were studied. The onset of this dermatosis was delayed until adulthood. The eruption consisted of scaly papules 1-5 mm in diameter which developed principally on the lower legs, upper arms and pinnae. Histopathologically there were discrete foci of hyperkeratosis with some parakeratosis over an attenuated and partially spongiotic epidermis. A genetic influence in this disorder was suggested by its occurrence in sisters in two families and in a mother and daughter. Immunohistochemical and biochemical studies suggested that there is a disorder of keratinocyte proliferation in the disease.
对12例患有剥脱性角质松解症的女性患者的临床和组织病理学特征进行了研究。这种皮肤病的发病延迟至成年期。皮疹由直径1-5毫米的鳞屑性丘疹组成，主要发生在小腿、上臂和耳廓。组织病理学上，在变薄且部分海绵形成的表皮上有离散的角化过度灶，并伴有一些不全角化。该病在两个家族的姐妹以及一对母女中出现，提示有遗传影响。免疫组织化学和生化研究表明，该病存在角质形成细胞增殖紊乱。
