一种用于前列腺近距离放射治疗的动态剂量测定系统。
A Dynamic Dosimetry System for Prostate Brachytherapy.
作者信息
Kuo Nathanael, Dehghan Ehsan, Deguet Anton, Song Danny Y, Prince Jerry L, Lee Junghoon
机构信息
Dept. of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Philips Research North America, Briarcliff Manor, NY, USA.
出版信息
Proc SPIE Int Soc Opt Eng. 2013 Mar 8;8671. doi: 10.1117/12.2008097.
The lack of dynamic dosimetry tools for permanent prostate brachytherapy causes otherwise avoidable problems in prostate cancer patient care. The goal of this work is to satisfy this need in a readily adoptable manner. Using the ubiquitous ultrasound scanner and mobile non-isocentric C-arm, we show that dynamic dosimetry is now possible with only the addition of an arbitrarily configured marker-based fiducial. Not only is the system easily configured from accessible hardware, but it is also simple and convenient, requiring little training from technicians. Furthermore, the proposed system is built upon robust algorithms of seed segmentation, fiducial detection, seed reconstruction, and image registration. All individual steps of the pipeline have been thoroughly tested, and the system as a whole has been validated on a study of 25 patients. The system has shown excellent results of accurately computing dose, and does so with minimal manual intervention, therefore showing promise for widespread adoption of dynamic dosimetry.
永久性前列腺近距离放射治疗缺乏动态剂量测定工具，这在前列腺癌患者护理中导致了原本可以避免的问题。这项工作的目标是以一种易于采用的方式满足这一需求。通过使用普遍存在的超声扫描仪和移动非等中心C形臂，我们表明，只需添加一个任意配置的基于标记的基准，现在就可以进行动态剂量测定。该系统不仅可以通过易于获取的硬件轻松配置，而且简单方便，技术人员几乎无需培训。此外，所提出的系统基于种子分割、基准检测、种子重建和图像配准的强大算法构建。管道的所有单个步骤都经过了全面测试，并且该系统在对25名患者的研究中得到了验证。该系统在准确计算剂量方面显示出优异的结果，并且只需最少的人工干预即可做到这一点，因此显示出动态剂量测定广泛应用的前景。
Zotero 插件