Alcon Research, Ltd., a Novartis Company.
J Pharm Pharm Sci. 2013;16(5):683-707. doi: 10.18433/j3ww34.
The eye is a very complex sensory organ consisting of numerous structures to coordinate the function of sight. It has a series of physical and chemical barriers to help maintain its homeostasis, and mediate environmental exposures. Transporters in the eye play a very important role in maintaining homeostasis by facilitating the movement of ions, nutrients and xenobiotics to various tissues in the eye, especially to non-vascular tissues like the lens and cornea. They also ensure proper cell signaling by shuttling neurotransmitters within the retina. Thus, they are expected to play an important role in determining the ocular exposure of drugs and other pharmacotherapeutics. However, the role of ocular transporters in ophthalmic drug delivery and their clinical relevance has not been well characterized. The purpose of the present review is to summarize the current evidence in the literature on ocular drug transporters and their role in ocular drug delivery, with the emphasis predominantly on their role in ocular pharmacokinetics.
眼睛是一个非常复杂的感觉器官，由许多结构协调视觉功能。它有一系列的物理和化学屏障来帮助维持其体内平衡，并调节环境暴露。眼睛中的转运蛋白通过促进离子、营养物质和外源性物质向眼睛的各种组织，特别是向非血管组织如晶状体和角膜的运动，在维持体内平衡方面发挥着非常重要的作用。它们还通过在视网膜内穿梭神经递质来确保适当的细胞信号转导。因此，它们有望在确定药物和其他药物治疗的眼部暴露方面发挥重要作用。然而，眼部转运蛋白在眼科药物输送中的作用及其临床相关性尚未得到很好的描述。本综述的目的是总结文献中关于眼部药物转运蛋白及其在眼部药物输送中的作用的现有证据，重点主要是它们在眼部药代动力学中的作用。
