贻贝启发的聚多巴胺包覆介孔二氧化硅纳米粒子作为用于控释的pH敏感纳米载体。
Mussel-inspired polydopamine coated mesoporous silica nanoparticles as pH-sensitive nanocarriers for controlled release.
作者信息
Zheng Qishan, Lin Tianran, Wu Hanyin, Guo Liangqia, Ye Peirong, Hao Yanli, Guo Qingquan, Jiang Jinzhi, Fu Fengfu, Chen Guonan
机构信息
Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety and Department of Chemistry, Fuzhou University, Fuzhou 350108, PR China.
Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety and Department of Chemistry, Fuzhou University, Fuzhou 350108, PR China.
出版信息
Int J Pharm. 2014 Mar 10;463(1):22-6. doi: 10.1016/j.ijpharm.2013.12.045. Epub 2014 Jan 4.
A novel pH-sensitive controlled release system is proposed by using mussel-inspired polydopamine (PDA) coated mesoporous silica nanoparticles (MSNs) as nanocarriers. MSNs with a large pore diameter are synthesized by using 1,3,5-trimethylbenzene as a pore-expanding agent and are modified with a PDA coating by virtue of oxidative self-polymerization of dopamine in neutral pH. PDA coated MSNs are characterized by FTIR, TEM, N₂ adsorption and XPS techniques. The PDA coating can work as pH-sensitive gatekeepers to control the release of drug molecules from MSNs in response to the pH-stimulus. Doxorubicin (DOX, an anticancer drug) can be released in the acid media and blocked in the neutral media.
提出了一种新型的pH敏感控释系统，该系统使用受贻贝启发的聚多巴胺（PDA）包覆的介孔二氧化硅纳米颗粒（MSNs）作为纳米载体。以1,3,5-三甲基苯作为扩孔剂合成了大孔径的MSNs，并通过多巴胺在中性pH下的氧化自聚合用PDA涂层进行修饰。采用傅里叶变换红外光谱（FTIR）、透射电子显微镜（TEM）、N₂吸附和X射线光电子能谱（XPS）技术对PDA包覆的MSNs进行了表征。PDA涂层可作为pH敏感的守门人，响应pH刺激控制药物分子从MSNs中的释放。阿霉素（DOX，一种抗癌药物）可在酸性介质中释放，而在中性介质中被阻断。
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