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用于抗肿瘤药物靶向递送系统的介孔二氧化硅纳米颗粒的表面修饰

Surface Modification of Mesoporous Silica Nanoparticles for Application in Targeted Delivery Systems of Antitumour Drugs.

作者信息

Kovtareva Svetlana, Kusepova Lyazat, Tazhkenova Gaukhar, Mashan Togzhan, Bazarbaeva Karlygash, Kopishev Eldar

机构信息

Department of Chemistry, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan.

出版信息

Polymers (Basel). 2024 Apr 16;16(8):1105. doi: 10.3390/polym16081105.

DOI:10.3390/polym16081105
PMID:38675024
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11054758/
Abstract

The problem of tumour therapy has attracted the attention of many researchers for many decades. One of the promising strategies for the development of new dosage forms to improve oncology treatment efficacy and minimise side effects is the development of nanoparticle-based targeted transport systems for anticancer drugs. Among inorganic nanoparticles, mesoporous silica deserves special attention due to its outstanding surface properties and drug-loading capability. This review analyses the various factors affecting the cytotoxicity, cellular uptake, and biocompatibility of mesoporous silica nanoparticles (MSNs), constituting a key aspect in the development of safe and effective drug delivery systems. Special attention is paid to technological approaches to chemically modifying MSNs to alter their surface properties. The stimuli that regulate drug release from nanoparticles are also discussed, contributing to the effective control of the delivery process in the body. The findings emphasise the importance of modifying MSNs with different surface functional groups, bio-recognisable molecules, and polymers for their potential use in anticancer drug delivery systems.

摘要

几十年来，肿瘤治疗问题一直吸引着众多研究人员的关注。开发新剂型以提高肿瘤治疗效果并将副作用降至最低的一种有前景的策略是开发基于纳米颗粒的抗癌药物靶向运输系统。在无机纳米颗粒中，介孔二氧化硅因其出色的表面性质和载药能力而值得特别关注。本综述分析了影响介孔二氧化硅纳米颗粒（MSN）细胞毒性、细胞摄取和生物相容性的各种因素，这是开发安全有效的药物递送系统的关键方面。特别关注通过化学修饰MSN来改变其表面性质的技术方法。还讨论了调节纳米颗粒药物释放的刺激因素，这有助于有效控制体内递送过程。研究结果强调了用不同的表面官能团、生物可识别分子和聚合物修饰MSN对于其在抗癌药物递送系统中的潜在应用的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/92fca0464e82/polymers-16-01105-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/cd9e45840d60/polymers-16-01105-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/807410a4ca13/polymers-16-01105-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/be7c88d1d15b/polymers-16-01105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/e25a33dfd55c/polymers-16-01105-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/713010e54867/polymers-16-01105-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/b8f3a543ba78/polymers-16-01105-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/bc6d87fd010a/polymers-16-01105-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/20442c4d55fc/polymers-16-01105-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/d1ee146e08b4/polymers-16-01105-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/c1e5ac07c4b5/polymers-16-01105-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/4da867c6ec09/polymers-16-01105-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/ed1c8ca3bfb3/polymers-16-01105-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/5dae2539132e/polymers-16-01105-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/7ed9178cc761/polymers-16-01105-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/92fca0464e82/polymers-16-01105-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/cd9e45840d60/polymers-16-01105-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/807410a4ca13/polymers-16-01105-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/be7c88d1d15b/polymers-16-01105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/e25a33dfd55c/polymers-16-01105-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/713010e54867/polymers-16-01105-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/b8f3a543ba78/polymers-16-01105-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/bc6d87fd010a/polymers-16-01105-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/20442c4d55fc/polymers-16-01105-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/d1ee146e08b4/polymers-16-01105-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/c1e5ac07c4b5/polymers-16-01105-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/4da867c6ec09/polymers-16-01105-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/ed1c8ca3bfb3/polymers-16-01105-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/5dae2539132e/polymers-16-01105-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/7ed9178cc761/polymers-16-01105-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3367/11054758/92fca0464e82/polymers-16-01105-g015.jpg

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[4]
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[5]
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本文引用的文献

[1]
Temozolomide and chloroquine co-loaded mesoporous silica nanoparticles are effective against glioma.

Heliyon. 2023-7-20

[2]
Interpolymer Complexes Based on Cellulose Ethers: Application.

Polymers (Basel). 2023-8-7

[3]
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Ann Surg Oncol. 2023-9

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Pharmaceutics. 2023-2-28

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