Kawaguchi Kei, Motoi Fuyuhiko, Yokoyama Satoru, Takemura Shinichi, Doi Takashi, Nozawa Yoshihiro, Fujishima Fumiyoshi, Unno Michiaki, Kuroda Fusakuni
Division of Hepato-Biliary-Pancreatic Surgery, Tohoku University Hospital.
Gan To Kagaku Ryoho. 2013 Nov;40(12):1875-7.
A man in his 40s had a locally advanced pancreatic head cancer invading the portal vein( PV) and common hepatic artery (CHA). He underwent 5 courses of neoadjuvant chemotherapy( gemcitabine+S-1), which reduced the tumor volume and cancer antigen 19-9 (CA19-9) level. R0 resection was performed via sub-stomach preserving pancreatoduodenectomy with combined resection of the PV and CHA. Adjuvant chemotherapy with gemcitabine was administered at 4 weeks after the operation. Relevant neoadjuvant chemotherapy is considered to contribute to R0 resection of locally advanced pancreatic cancer. Here, we report a case of a successful R0 resection after neoadjuvant chemotherapy for locally advanced pancreatic cancer.
一名40多岁男性患有局部进展期胰头癌,侵犯门静脉(PV)和肝总动脉(CHA)。他接受了5个疗程的新辅助化疗(吉西他滨+S-1),这使肿瘤体积和癌抗原19-9(CA19-9)水平降低。通过保留胃的胰十二指肠切除术联合PV和CHA切除进行了R0切除。术后4周给予吉西他滨辅助化疗。相关新辅助化疗被认为有助于局部进展期胰腺癌的R0切除。在此,我们报告一例局部进展期胰腺癌新辅助化疗后成功R0切除的病例。