翻译起始因子 4G 在寿命调控和与年龄相关的健康中的作用。
Role of translation initiation factor 4G in lifespan regulation and age-related health.
机构信息
Davis Center for Regenerative Biology and Medicine, Mount Desert Island Biological Laboratory, 159 Old Bar Harbor Road, Salisbury Cove, ME 04672, USA.
出版信息
Ageing Res Rev. 2014 Jan;13:115-24. doi: 10.1016/j.arr.2013.12.008. Epub 2014 Jan 3.
Abstract
Inhibiting expression of eukaryotic translation initiation factor 4G (eIF4G) arrests normal development but extends lifespan when suppressed during adulthood. In addition to reducing overall translation, inhibition alters the stoichiometry of mRNA translation in favor of genes important for responding to stress and against those associated with growth and reproduction in C. elegans. In humans, aberrant expression of eIF4G is associated with certain forms of cancer and neurodegeneration. Here we review what is known about the roles of eIF4G in molecular, cellular, and organismal contexts. Also discussed are the gaps in understanding of this factor, particularly with regard to the roles of specific forms of expression in individual tissues and the importance of understanding eIF4G for development of potential therapeutic applications.
摘要
抑制真核翻译起始因子 4G（eIF4G）的表达会阻止正常发育，但在成年后抑制其表达会延长寿命。除了降低整体翻译水平外，抑制作用还改变了 mRNA 翻译的化学计量，有利于对抗生长和繁殖相关基因，而有利于对抗那些与压力反应相关的基因。在人类中，eIF4G 的异常表达与某些形式的癌症和神经退行性变有关。在这里，我们回顾了 eIF4G 在分子、细胞和机体水平上的作用。还讨论了对该因子的理解存在的差距，特别是在个体组织中特定表达形式的作用以及理解 eIF4G 对潜在治疗应用的发展的重要性方面。
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