HumProTher Laboratory, TheREx, TIMC-IMAG Laboratory, CNRS UMR5525, University Joseph Fourier, 38700, La Tronche, Cedex, France.
Cell Mol Life Sci. 2013 Oct;70(19):3603-16. doi: 10.1007/s00018-013-1263-y. Epub 2013 Jan 25.
The regulation of the protein synthesis has a crucial role in governing the eukaryotic cell growth. Subtle changes of proteins involved in the translation process may alter the rate of the protein synthesis and modify the cell fate by shifting the balance from normal status into a tumoral or apoptotic one. The largest eukaryotic initiation factor involved in translation regulation is eIF3. Amongst the 13 factors constituting eIF3, the f subunit finely regulates this balance in a cell-type-specific manner. Loss of this factor causes malignancy in several cells, and atrophy in normal muscle cells. The intracellular interacting partners which influence its physiological significance in both cancer and muscle cells are detailed in this review. By delineating the global interaction network of this factor and by clarifying its intracellular role, it becomes apparent that the f subunit represents a promising candidate molecule to use for biotherapeutic applications.
蛋白质合成的调控在调控真核细胞生长中起着关键作用。参与翻译过程的蛋白质的细微变化可能会改变蛋白质合成的速度，并通过将平衡从正常状态转移到肿瘤或凋亡状态来改变细胞命运。参与翻译调控的最大的真核起始因子是 eIF3。在构成 eIF3 的 13 个因子中，f 亚基以细胞类型特异性的方式精细调节这种平衡。该因子的缺失会导致多种细胞发生恶性肿瘤，并导致正常肌肉细胞萎缩。本文详细介绍了影响其在癌细胞和肌肉细胞中生理意义的细胞内相互作用伙伴。通过描绘该因子的全局相互作用网络并阐明其细胞内作用，显然 f 亚基代表了一个有前途的候选分子，可用于生物治疗应用。
