Fischer J F
Ann Anesthesiol Fr. 1977;18(12):966-74.
We have attempted to trace the development of the concept which stresses that the encephalopathy often seen with hepatic failure may be the result of derangement in amino acid metabolism in patients with failing livers. We have also proposed that the infusion of solutions which may normalize these plasma amino acids and decrease the amount of toxic aromatic amino acids within the circulation may help in the amelioration of the symptoms of hepatic encephalopathy. We believe that in our studies to date, the use of this solution has been a significant advantage in the care of these extremely ill patients. We would hope that when the solution becomes generally available, the provision of such solutions to such patients will result in the salvage of some lives lost at the present time because of hepatic failure and encephalopathy.
我们试图追溯这一概念的发展历程，该概念强调，肝功能衰竭时常见的脑病可能是肝脏功能衰退患者氨基酸代谢紊乱的结果。我们还提出，输注可使这些血浆氨基酸正常化并减少循环中毒性芳香族氨基酸数量的溶液，可能有助于改善肝性脑病的症状。我们认为，在我们迄今为止的研究中，使用这种溶液对护理这些重症患者具有显著优势。我们希望，当这种溶液普遍可得时，为这类患者提供此类溶液将挽救一些目前因肝功能衰竭和脑病而失去的生命。
