经颅超声检查在 1 型肌强直性营养不良患者中的应用。
Transcranial sonography in patients with myotonic dystrophy type 1.
机构信息
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, 6 Dr Subotica Street, 11000, Belgrade, Serbia.
出版信息
Muscle Nerve. 2014 Aug;50(2):278-82. doi: 10.1002/mus.24162. Epub 2014 May 15.
INTRODUCTION
In this study we analyzed transcranial sonography (TCS) in patients with myotonic dystrophy type 1 (DM1).
METHODS
This cross-sectional study included 66 DM1 patients and 55 matched healthy controls (HCs). Echogenicity of the brainstem raphe (BR) and substantia nigra (SN) and third ventricle width (DTV) were assessed by TCS.
RESULTS
BR hypoechogenicity was more common in DM1 patients than in HCs (37.7% vs. 7.8%, P < 0.01). Patients with depression or fatigue were more likely to have BR hypoechogenicity (80.0% vs. 29.4%, P < 0.01 and 51.9% vs. 24.2%, P < 0.05, respectively). Both hypoechogenicity and hyperechogenicity of SN were more frequent in DM1 patients than in controls (26.2% vs. 10.9% and 13.1% vs. 1.8%, respectively, P < 0.01). DTV was increased in DM1 patients compared with HCs (6.0 ± 1.4 vs. 4.9 ± 0.9 mm, P < 0.01).
CONCLUSION
TCS can offer new insight into structural changes of several cerebral areas in patients with DM1.
简介
本研究分析了 1 型肌强直性营养不良（DM1）患者的经颅超声（TCS）。
方法
本横断面研究纳入了 66 例 DM1 患者和 55 名匹配的健康对照（HC）。通过 TCS 评估脑桥中缝（BR）和黑质（SN）的回声强度以及第三脑室宽度（DTV）。
结果
与 HCs 相比，DM1 患者的 BR 低回声更为常见（37.7% vs. 7.8%，P<0.01）。患有抑郁或疲劳的患者更可能出现 BR 低回声（80.0% vs. 29.4%，P<0.01 和 51.9% vs. 24.2%，P<0.05）。与 HCs 相比，DM1 患者的 SN 低回声和高回声均更为常见（26.2% vs. 10.9% 和 13.1% vs. 1.8%，均 P<0.01）。与 HCs 相比，DM1 患者的 DTV 增加（6.0±1.4 vs. 4.9±0.9 mm，P<0.01）。
结论
TCS 可提供 DM1 患者多个脑区结构变化的新见解。
Zotero 插件