FEBS Lett. 2013 Nov 29;587(23):3875-82.
MicroRNAs mainly inhibit coding genes and long non-coding RNA expression. Here, we report that hsa-miR-125b and oncogene SIRT7/oncogenic long non-coding RNA MALAT1 were inversely expressed in bladder cancer. Hsa-miR-125b mimic down-regulated, whereas hsa-miR-125b inhibitor up-regulated the expression of SIRT7 and MALAT1. Binding sites were confirmed between hsa-miR-125b and SIRT7/MALAT1. Up-regulation of hsa-miR-125b or down-regulation of SIRT7 inhibited proliferation, motility and increased apoptosis. The effects of up-regulation of hsa-miR-125b were similar to that of silencing MALAT1 in bladder cancer as we had previously described. These data suggest that hsa-miR-125b suppresses bladder cancer development via inhibiting SIRT7 and MALAT1.
微小 RNA 主要抑制编码基因和长非编码 RNA 的表达。在这里，我们报告在膀胱癌中 hsa-miR-125b 和癌基因 SIRT7/致癌长非编码 RNA MALAT1 呈负相关表达。hsa-miR-125b 模拟物下调，而 hsa-miR-125b 抑制剂上调 SIRT7 和 MALAT1 的表达。hsa-miR-125b 和 SIRT7/MALAT1 之间存在结合位点。上调 hsa-miR-125b 或下调 SIRT7 抑制增殖、迁移并增加凋亡。上调 hsa-miR-125b 的作用与我们之前描述的沉默 MALAT1 相似。这些数据表明 hsa-miR-125b 通过抑制 SIRT7 和 MALAT1 抑制膀胱癌的发展。
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