Wang Cheng, Wang Tao, Zhou Nan, Pan Xiao-Yan, He Huai-Zhen
a School of Medicine, Xi'an Jiaotong University , Xi'an , 710061 , China.
J Asian Nat Prod Res. 2014;16(3):304-11. doi: 10.1080/10286020.2013.874345. Epub 2014 Jan 8.
Two new 9-hydroxy-7H-furo[3,2-g]chromen-7-one derivatives were designed, synthesized and evaluated for their in vitro vasodilatory activity. The structures of two compounds were elucidated by infrared, ¹H NMR, and mass spectral data. The in vitro pharmacological evaluation indicated that both of them possessed well vasodilatory activity compared with imperatorin. The molecule docking also showed two target compounds docked well with L-calcium channel (PDB code: 3G43). The result suggested that they would be potential vasodilatory agents for hypertension.
设计、合成了两种新型9-羟基-7H-呋喃并[3,2-g]色原酮-7-酮衍生物，并对其体外血管舒张活性进行了评价。通过红外光谱、¹H NMR和质谱数据对两种化合物的结构进行了鉴定。体外药理评价表明，与欧前胡素相比，它们均具有良好的血管舒张活性。分子对接也显示两种目标化合物与L-钙通道（PDB代码：3G43）对接良好。结果表明它们可能是治疗高血压的潜在血管舒张剂。
