Department of Internal Medicine and Medical Disciplines, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Expert Rev Pharmacoecon Outcomes Res. 2014 Feb;14(1):113-21. doi: 10.1586/14737167.2014.873702. Epub 2014 Jan 7.
The clinical picture of primary hyperparathyroidism (PHPT) has changed over the last three decades and many asymptomatic patients are now diagnosed through the unexpected finding of high serum calcium levels. However, though not yet considered as typical features of the disease and therefore not included in the guidelines for surgery, many data are available on neuropsycological manifestations and their impact on quality of life in asymptomatic patients. PHPT patients indeed show early experience nonspecific symptoms, such as weakness, depression, sleep disturbance, memory loss and anxiety. Although the underlining mechanisms have not been still identified, the prevalence of psychiatric and cognitive deficits has been investigated in many studies, as well as the possible association with quality of life and well-being improvement after surgery. This article aims to review the current knowledge on quality of life in PHPT patients before and after surgery and the possible clinical implications of these findings.
原发性甲状旁腺功能亢进症（PHPT）的临床表现在过去三十年中发生了变化，许多无症状患者现在通过意外发现血清钙水平升高而被诊断出来。然而，尽管这些表现尚未被认为是该疾病的典型特征，因此未被纳入手术指南，但已有许多关于无症状患者神经心理表现及其对生活质量影响的数据。PHPT 患者确实会出现早期非特异性症状，如乏力、抑郁、睡眠障碍、记忆力减退和焦虑。尽管潜在机制尚未确定，但许多研究已经调查了精神和认知缺陷的患病率，以及手术后生活质量和幸福感改善的可能关联。本文旨在综述 PHPT 患者手术前后生活质量的最新知识及其对临床的可能影响。
