Giembycz M A, Rodger I W
Life Sci. 1987 Jul 13;41(2):111-32. doi: 10.1016/0024-3205(87)90485-1.
In this article the electrophysiological events which are believed to underly agonist-induced contraction and relaxation of airway smooth muscle are reviewed, with special emphasis on the indispensable role of the Ca ion. The contribution made by Na, K, Ca and Cl to, and the role that the electrogenic Na:K-dependent ATPase plays in, the maintenance of the resting membrane potential in both normal and sensitised airway smooth muscle cells is described together with the permeability changes that occur in the plasmalemma in response to excitatory and inhibitory agonists. In addition, the currently available evidence for the existence of potential-sensitive and receptor-operated Ca channels in respiratory smooth muscle, and how such channels may be involved in the regulation of airway calibre, is critically assessed.
本文回顾了被认为是气道平滑肌激动剂诱导收缩和舒张基础的电生理事件，特别强调了钙离子的不可或缺的作用。描述了钠、钾、钙和氯对正常和致敏气道平滑肌细胞静息膜电位维持的贡献，以及电生性钠钾依赖ATP酶在其中所起的作用，同时还描述了质膜响应兴奋性和抑制性激动剂时发生的通透性变化。此外，对目前关于呼吸平滑肌中电压敏感钙通道和受体操纵钙通道存在的证据，以及此类通道如何参与气道管径调节进行了批判性评估。
