Popescu Mihaela N, Ionescu Elena, Iovănescu L C, Cotoi B V, Popescu A I, Gănescu Anca Elena, Glodeanu Adina, Geormăneanu Cristiana, Moraru Andreiana, Pătraşcu Anca
Department of Endocrinology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;
Rom J Morphol Embryol. 2013;54(4):1075-80.
Some hypophyseal adenomas are discrete, well-marked lesions, which can be curatively removed by surgical resection, while others seem aggressive, invasive, recidive-prone, most often progressing in spite of any pharmacological, surgical or radiotherapeutical interventions. There is also a great variability within the incidence of aggression and invasion among the various types of hypophyseal immunotypes. Despite their well-differentiated nature and their "benign" constitution, an important number of hypophyseal tumors will be surely invasive within the sclerous, osseous and neural structures. Because the aggressive behavior of invasive adenomas is generally resolved by surgical treatment, this aspect of their biology does not perfectly reflect within their histopathological aspect. In fact, the invasive tumors with local extreme aggression are most often deceiving due to their relatively harmless histopathological aspect. The usual morphological signs of tumor aggression, namely pleomorphism, nuclear atypia, hemorrhage, high cellular and mitotic activity, poorly correlate with the invasive potential of pituitary tumors, with their proliferation capacity, their tendency of post-surgical recurrence or with their global biological behavior.
一些垂体腺瘤是界限清楚、特征明显的病变，可通过手术切除治愈，而另一些则似乎具有侵袭性、易复发，尽管采取了任何药物、手术或放射治疗干预措施，仍常常进展。在各种垂体免疫类型中，侵袭和侵犯的发生率也存在很大差异。尽管垂体瘤具有分化良好的性质和“良性”构成，但相当数量的垂体瘤肯定会侵犯硬脑膜、骨质和神经结构。由于侵袭性腺瘤的侵袭性行为通常通过手术治疗得到解决，其生物学的这一方面在组织病理学方面并未得到完美体现。事实上，具有局部极端侵袭性的侵袭性肿瘤由于其相对无害的组织病理学表现，常常具有欺骗性。肿瘤侵袭的常见形态学征象，即多形性、核异型性、出血、高细胞活性和有丝分裂活性，与垂体肿瘤的侵袭潜能、增殖能力、术后复发倾向或整体生物学行为相关性较差。
