Department of Physics, University of Helsinki, Helsinki, Finland.
Physiol Meas. 2014 Feb;35(2):139-51. doi: 10.1088/0967-3334/35/2/139. Epub 2014 Jan 7.
Sedative drugs decrease postural steadiness and increase the risk of injury from falls and accidents. The recovery rate is individual, making it hard to predict the patient's steadiness and hence safe discharge time. 103 outpatients sedated with midazolam and fentanyl were measured posturographically, before (PRE) and after (POST) endoscopy. The ability of conventional and nonlinear sway measures to separate the PRE and POST conditions were compared, and the area under the receiver operating characteristics curve (AUC) was used to quantify the significance of the separation. A nonlinear measure, fuzzy sample entropy, scored the largest AUC (AUCFSE = 0.83, p < 0.0001). While the AUCFSE was not significantly larger than the AUCs of conventional sway measures which offer easy quantification of postural steadiness, nonlinear measures provide more insight into the structure of postural control, which may help understand the effect of sedation on postural steadiness. This study is a step toward developing a tester that indicates a safe discharge time.
镇静药物会降低姿势稳定性，并增加跌倒和事故受伤的风险。恢复速度因人而异，因此很难预测患者的稳定性，从而确定安全的出院时间。对 103 名接受咪达唑仑和芬太尼镇静的门诊患者进行了姿势描记术测量，分别在（PRE）内镜检查前和（POST）内镜检查后。比较了常规和非线性摆动测量值分离 PRE 和 POST 条件的能力，并使用受试者工作特征曲线下的面积（AUC）来量化分离的显著性。一种非线性测量方法，模糊样本熵，获得了最大 AUC（AUCFSE=0.83，p<0.0001）。虽然 AUCFSE 并不明显大于常规摆动测量值的 AUC，常规摆动测量值可以很容易地量化姿势稳定性，但非线性测量值提供了对姿势控制结构的更深入了解，这可能有助于理解镇静对姿势稳定性的影响。本研究是朝着开发一种能够指示安全出院时间的测试器迈出的一步。
