Saglam Gulis, Gunduz Ozgur, Ulugol Ahmet
Department of Medical Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey.
Acta Neurol Belg. 2014 Dec;114(4):307-9. doi: 10.1007/s13760-013-0272-9. Epub 2014 Jan 8.
Cannabinoid CB1 receptors have been shown to mediate the antinociceptive, but not the hypothermic, action of the worldwide used analgesic, paracetamol. Since itch and pain sensations share many similarities, the purpose of the present study was to investigate whether blockade of cannabinoid CB1 and CB2 receptors participates in the antipruritic activity of paracetamol in mice. Scratching behavior was induced by intradermal serotonin injection into the rostral part of the back of the mice. After serotonin administration, scratching of the injected site by the hind paws were videotaped and counted for 30 min. Serotonin-induced scratching behavior was attenuated with high-dose paracetamol (300 mg/kg). The CB1 receptor antagonist, AM-251 (1 mg/kg), and the CB2 receptor antagonist, SR-144528 (1 mg/kg), did not alter the anti-scratching behavioral effect of paracetamol. Our results indicate that, in contrast to its antinociceptive action, but similar to its hypothermic effect, cannabinoid receptors are not involved in the antipruritic activity of paracetamol.
大麻素CB1受体已被证明介导全球广泛使用的镇痛药对乙酰氨基酚的镇痛作用，但不介导其降温作用。由于瘙痒和疼痛感觉有许多相似之处，本研究的目的是调查大麻素CB1和CB2受体的阻断是否参与对乙酰氨基酚对小鼠的止痒活性。通过向小鼠背部头侧皮内注射血清素诱导搔抓行为。给予血清素后，用后爪搔抓注射部位的行为进行录像，并计数30分钟。高剂量对乙酰氨基酚（300mg/kg）可减轻血清素诱导的搔抓行为。CB1受体拮抗剂AM-251（1mg/kg）和CB2受体拮抗剂SR-144528（1mg/kg）并未改变对乙酰氨基酚的抗搔抓行为效应。我们的结果表明，与对乙酰氨基酚的镇痛作用相反，但与其降温作用相似，大麻素受体不参与对乙酰氨基酚的止痒活性。
