胃肠道神经内分泌肿瘤25年

25 Years of neuroendocrine neoplasms of the gastrointestinal tract.

作者信息

Rindi G, Petrone G, Inzani F

机构信息

Institute of Pathology, Università Cattolica del Sacro Cuore - Policlinico A. Gemelli, Largo A. Gemelli, 8, 00168, Rome, Italy,

出版信息

Endocr Pathol. 2014 Mar;25(1):59-64. doi: 10.1007/s12022-013-9292-5.

DOI:10.1007/s12022-013-9292-5

PMID:24399298

Abstract

This paper provides a personal pathologist's view of how neuroendocrine tumors (NET) were perceived and defined in the last quarter of a century. In years when the Helicobacter pylori, omeprazole and the adenoma-carcinoma sequence in colon carcinogenesis significantly impacted on gastrointestinal (GI) pathology daily practice, neuroendocrine neoplasms of the GI tract passed from the original carcinoid definition to the current NET and neuroendocrine carcinoma (NEC) definitions. The development of different concepts, basic tumor biology knowledge, tools for pathology diagnosis and the various World Health Organization (WHO) classifications from 1980 through 2010 are briefly reviewed and discussed.

摘要

本文呈现了一位病理学家个人对过去四分之一个世纪里神经内分泌肿瘤（NET）的认知与定义的看法。在幽门螺杆菌、奥美拉唑以及结肠癌变过程中的腺瘤-癌序列对胃肠（GI）病理学日常实践产生重大影响的那些年里，胃肠道神经内分泌肿瘤从最初的类癌定义转变为当前的神经内分泌肿瘤（NET）和神经内分泌癌（NEC）定义。简要回顾并讨论了从1980年到2010年不同概念的发展、肿瘤生物学基础知识、病理诊断工具以及世界卫生组织（WHO）的各种分类。