Tran Loi V
Intensive Care Unit, Holy Cross Hospital, Silver Spring, Maryland.
J Trauma Nurs. 2014 Jan-Feb;21(1):30-5. doi: 10.1097/JTN.0000000000000026.
Traumatic brain injury continues to be a major socioeconomic problem, costing the United States $76.5 billion in the year of 2000. Despite the advances in the field of medicine, there are still no definitive treatments for traumatic brain injury. Goal of therapy is still gearing toward supportive cares such as intracranial pressure monitoring, lowering intracranial pressure, correcting cerebral ischemia, and manipulating serum osmolarity. The search for effective treatment in human studies has been unfruitful. In this review, the mechanisms of primary and secondary brain injury are discussed along with potential neuroprotective interventions such as hyperosmolar therapies, hypothermia, statins, and cyclosporin A.
创伤性脑损伤仍然是一个重大的社会经济问题，在2000年给美国造成了765亿美元的损失。尽管医学领域取得了进展，但创伤性脑损伤仍然没有确切的治疗方法。治疗目标仍然是倾向于支持性护理，如颅内压监测、降低颅内压、纠正脑缺血以及调节血清渗透压。在人体研究中寻找有效治疗方法一直没有成果。在这篇综述中，我们讨论了原发性和继发性脑损伤的机制以及潜在的神经保护干预措施，如高渗疗法、低温疗法、他汀类药物和环孢素A。
