Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland.
Pharmacol Rep. 2013;65(5):1401-6. doi: 10.1016/s1734-1140(13)71499-3.
Several clinical reports have suggested that the mirtazapine-induced augmentation of risperidone activity may effectively improve treatment of the negative and certain cognitive symptoms of schizophrenia.
The aim of the present study was to evaluate the effect of mirtazapine and risperidone, given separately or jointly, on the impact of MK-801(an NMDA receptor antagonist), given prior to the first introductory session, on the object recognition memory in mice. To this end, we used the object recognition test in which animals were tested for the ability to discriminate between an old, familiar and a novel object. Mirtazapine (2.5 or 5 mg/kg) and risperidone (0.01 mg/kg) were given 30 min before MK-801, and MK-801 (0.1 or 0.2 mg/kg) was administered 30 min before the first introductory session. Memory retention was evaluated 1.5 h after the introductory session.
The obtained results showed that MK-801 (0.2 mg/kg) decreased memory retention when given before the introductory session. Co-treatment with risperidone (0.01 mg/kg) and mirtazapine (2.5 or 5 mg/kg) abolished the effect of MK-801, whereas those drugs given separately did not change the action of MK-801.
The obtained results suggest that mirtazapine may enhance the antipsychotic-like effect of risperidone in the animal test modeling some cognitive symptoms of schizophrenia. Further studies are necessary to elucidate its mechanism of action.
一些临床报告表明，米氮平增强利培酮的活性可能有效地改善精神分裂症的阴性和某些认知症状的治疗效果。
本研究的目的是评估米氮平与利培酮分别或联合给药，对先前首次介绍性治疗前给予的 MK-801（一种 NMDA 受体拮抗剂）对小鼠物体识别记忆的影响。为此，我们使用物体识别测试，其中动物被测试其区分旧的、熟悉的和新的物体的能力。米氮平（2.5 或 5mg/kg）和利培酮（0.01mg/kg）在给予 MK-801 前 30 分钟给予，MK-801（0.1 或 0.2mg/kg）在首次介绍性治疗前 30 分钟给予。介绍性治疗后 1.5 小时评估记忆保留。
结果表明，MK-801（0.2mg/kg）在给予介绍性治疗前降低了记忆保留。与利培酮（0.01mg/kg）和米氮平（2.5 或 5mg/kg）联合治疗消除了 MK-801 的作用，而单独给予这些药物则没有改变 MK-801 的作用。
研究结果表明，米氮平可能增强利培酮在模拟精神分裂症某些认知症状的动物试验中的抗精神病样作用。需要进一步研究以阐明其作用机制。
