Cai Ting, Liu Zhi-Hong, Wang Zhi-Xin, Zhao Meng, Ju Hong-Li, Li Jin-Quan
Key Laboratory of Animal Genetics, Breeding and Reproduction, Inner Mongolia Agricultural University, Hohhot 010018, China.
Yi Chuan. 2013 Sep;35(9):1087-94. doi: 10.3724/sp.j.1005.2013.01087.
Epidermal development and cyclic hair follicle regeneration are governed by well-balanced programs of gene activation and silencing. Recent researches demonstrated that the expression profiles of miRNA showed tissue-specific expression patterns in the epidermis and hair follicles and stage-specific in cyclical development of hair follicles. Furthermore, a large number of miRNAs are involved in the development of epidermis and hair follicles, pigmentation, and the cyclical development of hair follicles. miRNAs in different cell types formed a comprehensive, multi-level network system through interaction with signal pathway and regulation factors. This review summarizes the available progress on how miRNAs are involved in the control of epidermal homeostasis and hair follicle development to enrich the research of gene regulatory networks and contribute to disease treatment and molecular breeding.
表皮发育和毛囊周期性再生受基因激活与沉默的平衡程序调控。近期研究表明，miRNA的表达谱在表皮和毛囊中呈现组织特异性表达模式，在毛囊的周期性发育中呈现阶段特异性。此外，大量miRNA参与表皮和毛囊的发育、色素沉着以及毛囊的周期性发育。不同细胞类型中的miRNA通过与信号通路和调控因子相互作用，形成了一个全面的、多层次的网络系统。本综述总结了miRNA如何参与表皮稳态和毛囊发育调控的现有进展，以丰富基因调控网络的研究，并为疾病治疗和分子育种做出贡献。
