三株对洋葱伯克霍尔德菌复合体（一种人类机会致病菌）产生抗菌化合物的南极嗜冷杆菌菌株的基因组草图。
Draft genomes of three Antarctic Psychrobacter strains producing antimicrobial compounds against Burkholderia cepacia complex, opportunistic human pathogens.
作者信息
Fondi Marco, Orlandini Valerio, Perrin Elena, Maida Isabel, Bosi Emanuele, Papaleo Maria Cristiana, Michaud Luigi, Lo Giudice Angelina, de Pascale Donatella, Tutino Maria Luisa, Liò Pietro, Fani Renato
机构信息
Laboratory of Microbial and Molecular Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Firenze, Italy; Computer Laboratory, Cambridge University, William Gates Building 15, JJ Thomson Avenue, Cambridge, United Kingdom.
Laboratory of Microbial and Molecular Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Firenze, Italy; Institute of Protein Biochemistry, National Research Council, Via P. Castellino, 111 I-80134 Naples, Italy.
出版信息
Mar Genomics. 2014 Feb;13:37-8. doi: 10.1016/j.margen.2013.12.009. Epub 2014 Jan 5.
Herein we present the draft genomes of three Psychrobacter strains isolated from Antarctic sponges and able to inhibit the growth of bacteria belonging to the Burkholderia cepacia complex, responsible for infections of the respiratory system in patients affected by Cystic Fibrosis. The comparative analysis of the annotated genomes of these Psychrobacter strains highlighted their differences in terms of overall genomic content (e.g. shared gene sets) and allowed the identification of gene clusters hypothetically involved in the biosynthesis of antimicrobial compounds.
在此，我们展示了从南极海绵中分离出的三株嗜冷杆菌菌株的基因组草图，这些菌株能够抑制洋葱伯克霍尔德菌复合体细菌的生长，该复合体细菌会导致囊性纤维化患者的呼吸系统感染。对这些嗜冷杆菌菌株注释基因组的比较分析突出了它们在整体基因组内容（如共享基因集）方面的差异，并使得能够鉴定出可能参与抗菌化合物生物合成的基因簇。
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