Philp David J, Korgaonkar Mayuresh S, Grieve Stuart M
The Brain Dynamics Centre, Sydney Medical School - Westmead, Sydney, NSW 2145, Australia; Westmead Millennium Institute, Westmead, Sydney, NSW 2145, Australia; Sydney Translational Imaging Laboratory, Sydney Medical School, University of Sydney, Camperdown, NSW 2050, Australia.
The Brain Dynamics Centre, Sydney Medical School - Westmead, Sydney, NSW 2145, Australia; Westmead Millennium Institute, Westmead, Sydney, NSW 2145, Australia; Sydney Translational Imaging Laboratory, Sydney Medical School, University of Sydney, Camperdown, NSW 2050, Australia; Discipline of Psychiatry, University of Sydney Medical School: Western, Westmead Hospital, Sydney, NSW 2145, Australia.
Neuroimage. 2014 May 1;91:77-83. doi: 10.1016/j.neuroimage.2013.12.057. Epub 2014 Jan 5.
Cognitive testing and diffusion tensor imaging data from 121 normal subjects were combined to investigate the relationship between thalamic connectivity and cognitive performance. Thalamic regions were segmented based on their cortical connectivity, and regions for both ipsilateral and contralateral thalamocortical connections were identified. White matter tracts corresponding to these regions were identified and the mean fractional anisotropy, and axial and radial diffusivities within each tract were measured. Motor task performance correlated with radial diffusivity in the dominant thalamo-precentral tract. Verbal memory corresponded with the thalamic volume connected to the left temporal lobe. These data support the use of diffusion tractography to identify functionally important regions within the thalamus. Our findings provide the first robust correlation between thalamic volumes and tract characteristics with cognitive performance data in normal subjects.
来自121名正常受试者的认知测试和扩散张量成像数据被合并起来，以研究丘脑连接性与认知表现之间的关系。根据丘脑的皮质连接性对丘脑区域进行分割，并识别同侧和对侧丘脑皮质连接的区域。识别出与这些区域相对应的白质束，并测量每条束内的平均分数各向异性、轴向扩散率和径向扩散率。运动任务表现与优势侧丘脑-中央前回束中的径向扩散率相关。言语记忆与连接到左侧颞叶的丘脑体积相对应。这些数据支持使用扩散束成像来识别丘脑中功能重要的区域。我们的研究结果首次在正常受试者中提供了丘脑体积和束特征与认知表现数据之间的有力关联。
