Qiu Yao-qin, Tang Yun-xiang, He Jia
School of Nursing, Second Military Medical University, Shanghai 200433, China.
Department of Health Statistics, Second Military Medical University, Shanghai 200433, China, Email:
Zhonghua Yi Xue Za Zhi. 2013 Nov 5;93(41):3261-4.
To explore the diagnostic application of receiver operating characteristic (ROC) curve of P300 amplitude and latency in schizophrenia.
ROC curve of P300 amplitude and latency was plotted from 91 first episode schizophrenia (FES) and 141 normal controls (NC). Youden's index and distance were calculated in ROC curve to determine the optimal cutoff point of P300 amplitude and latency for schizophrenic diagnosis. Then the subjects were layered by gender and age for improved diagnostic accuracy.
The area under ROC curve for P300 amplitude for predicting schizophrenia was 0.746 (P < 0.001), while P300 latency showed poor power in predicting schizophrenia (P = 0.373). The optimal cutoff point of P300 amplitude was 5.097 µV with a sensitivity of 80.14% and a specificity of 63.74%. After gender and age stratification, Youden' s index was enhanced in all 5 subgroups (from 1.8% to 14.88%) and the sensitivities of corresponding cutoff were enhanced obviously in subgroups of males (25.01%), ≤ 25 years (22.22%) and >40 years (28.80%) patients.
P300 amplitude has certain values in schizophrenic diagnosis. Gender and age stratification may enhance the diagnostic efficiency of ROC curve in the diagnosis of frequent schizophrenia.
探讨P300波幅和潜伏期的受试者工作特征（ROC）曲线在精神分裂症诊断中的应用。
绘制91例首发精神分裂症（FES）患者和141例正常对照（NC）的P300波幅和潜伏期的ROC曲线。计算ROC曲线中的约登指数和距离，以确定用于精神分裂症诊断的P300波幅和潜伏期的最佳截断点。然后按性别和年龄对受试者进行分层，以提高诊断准确性。
预测精神分裂症的P300波幅的ROC曲线下面积为0.746（P<0.001），而P300潜伏期在预测精神分裂症方面效能较差（P = 0.373）。P300波幅的最佳截断点为5.097µV，灵敏度为80.14%，特异度为63.74%。在按性别和年龄分层后，所有5个亚组的约登指数均有所提高（从1.8%至14.88%），男性亚组（25.01%）、≤25岁亚组（22.22%）和>40岁患者亚组（28.80%）相应截断点的灵敏度明显提高。
P300波幅在精神分裂症诊断中有一定价值。性别和年龄分层可能提高ROC曲线在常见精神分裂症诊断中的诊断效能。
