Vogel G L, Tenuta L M A, Schumacher G E, Chow L C
American Dental Association Foundation, Paffenbarger Research Center, Gaithersburg, Md., USA.
Caries Res. 2014;48(2):174-8. doi: 10.1159/000354047. Epub 2014 Jan 3.
The purpose of this study is to determine whether a calcium (Ca) prerinse used before a 228 µg/g (ppm) fluoride (F) rinse would induce the formation of 'calcium fluoride-like' (CaF2-like) deposits in human dental plaque. Sixty minutes after the use of the Ca prerinse/F rinse, plaque samples were collected from 10 volunteers, homogenized, and split into 2 aliquots. The plaque mass from one aliquot was then extracted with a 'plaque-like' solution that extracted all the CaF2-like deposits. The total F in both aliquots was then determined and compared. The results demonstrated that, as in previous studies, the Ca prerinse induced large increases in plaque fluid and total plaque F. However, unlike previous results without the Ca prerinse, 30% of the plaque F deposits were CaF2 or CaF2-like. Given that maintaining an elevated F concentration in the vicinity of a developing lesion may play an important role in the cariostatic effect of this ion, and the potential advantages of CaF2-like deposits as an F source, these results suggest that a Ca prerinse may increase the cariostatic effect of topical agents.
本研究的目的是确定在使用228微克/克（ppm）氟化物（F）漱口水之前进行钙（Ca）预冲洗是否会在人类牙菌斑中诱导形成“类氟化钙”（CaF₂样）沉积物。在使用钙预冲洗/氟漱口水60分钟后，从10名志愿者身上采集牙菌斑样本，进行均质化处理，并分成2份等分试样。然后用一种能提取所有CaF₂样沉积物的“类牙菌斑”溶液从其中一份等分试样中提取牙菌斑物质。接着测定并比较两份等分试样中的总氟含量。结果表明，与之前的研究一样，钙预冲洗导致牙菌斑液和总牙菌斑氟含量大幅增加。然而，与之前未进行钙预冲洗的结果不同，30%的牙菌斑氟沉积物为CaF₂或CaF₂样。鉴于在正在形成的病变附近维持较高的氟浓度可能在该离子的防龋作用中发挥重要作用，以及CaF₂样沉积物作为氟源的潜在优势，这些结果表明钙预冲洗可能会增强局部用剂的防龋效果。
