From the *Center for Human Nutrition, University of Texas Southwestern Medical Center, the Veterans Affairs Medical Center at Dallas; and †The Cooper Institute, Dallas, TX.
J Investig Med. 2014 Feb;62(2):345-9. doi: 10.2310/JIM.0000000000000044.
High triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) impart risk for heart disease. This study examines the relationships of TG/HDL-C ratio to mortality from all causes, coronary heart disease (CHD), or cardiovascular disease (CVD).
Survival analysis was done in 39,447 men grouped by TG/HDL-C ratio cut point of 3.5 and for metabolic syndrome. National Death Index International Classification of Diseases (ICD-9 and ICD-10) codes were used for CVD and CHD deaths occurring from 1970 to 2008. Incidence of type 2 diabetes mellitus (DM) according to ratio was estimated in 22,215 men. Triglyceride/HDL-C ratio and cross-product of TG and fasting blood glucose (TyG index) were used in analysis.
Men were followed up for 581,194 person-years. Triglyceride/HDL-C ratio predicted CHD, CVD, and all-cause mortality after adjustment for established risk factors and non-HDL-C. Mortality rates were higher in individuals with a high ratio than in those with a low ratio. Fifty-five percent of men had metabolic syndrome that was also predictive of CHD, CVD, and all-cause mortality. Annual incidence of DM was 2 times higher in men with high TG/HDL-C ratio than in those with a low ratio. Individuals with high TG/HDL-C ratio had a higher incidence of DM than those with a low ratio. The TyG index was not equally predictive of causes of mortality to TG/HDL-C, but both were equally predictive of diabetes incidence.
Triglyceride/HDL-C ratio predicts CHD and CVD mortality as well as or better than do metabolic syndrome in men. Also, a high ratio predisposes to DM. The TyG index does not predict CHD, CVD, or all-cause mortality equally well, but like TG/HDL-C ratio, it predicts DM incidence.
高甘油三酯（TG）和低高密度脂蛋白胆固醇（HDL-C）会增加患心脏病的风险。本研究探讨了 TG/HDL-C 比值与全因死亡率、冠心病（CHD）或心血管疾病（CVD）的关系。
对 39447 名男性进行生存分析，根据 TG/HDL-C 比值切点 3.5 分组，并对代谢综合征进行分组。国家死亡索引国际疾病分类（ICD-9 和 ICD-10）代码用于 1970 年至 2008 年期间发生的 CVD 和 CHD 死亡。根据比值估计了 22215 名男性的 2 型糖尿病（DM）发生率。在分析中使用了 TG/HDL-C 比值和 TG 与空腹血糖的乘积（TyG 指数）。
男性随访 581194 人年。调整了既定危险因素和非高密度脂蛋白胆固醇后，TG/HDL-C 比值预测 CHD、CVD 和全因死亡率。高比值个体的死亡率高于低比值个体。55%的男性患有代谢综合征，也可预测 CHD、CVD 和全因死亡率。高 TG/HDL-C 比值的男性患糖尿病的年发生率是低比值者的 2 倍。高 TG/HDL-C 比值个体的糖尿病发病率高于低比值者。TyG 指数与 TG/HDL-C 比值相比，预测死亡率的能力相当，但两者预测糖尿病发病率的能力相当。
在男性中，TG/HDL-C 比值预测 CHD 和 CVD 死亡率与代谢综合征相当或优于代谢综合征。此外，高比值易患糖尿病。TyG 指数与 TG/HDL-C 比值一样，不能同等准确地预测 CHD、CVD 或全因死亡率，但与 TG/HDL-C 比值一样，它可以预测糖尿病的发病率。
