共表达细胞角蛋白和神经丝蛋白的默克尔细胞肿瘤。

Merkel cell tumor coexpressing cytokeratin and neurofilament proteins.

作者信息

Sadahira Y, Nakamoto S, Mori M, Hsueh C L, Awai M

出版信息

Acta Pathol Jpn. 1987 Feb;37(2):331-7. doi: 10.1111/j.1440-1827.1987.tb03069.x.

DOI:10.1111/j.1440-1827.1987.tb03069.x

Abstract

Whorled filaments 10 nm in width were identified by anti-intermediate filaments antibodies in a Merkel cell tumor from a 52-year-old man. Immunohistochemical tests revealed that the tumor was stained with anti-keratin antibody and antibodies against the 68-kd and 200-kd subunits of neurofilament proteins but not antibody against the 150-kd subunit. This is the first reported case of Merkel cell tumor expressing a 200-kd subunit of neurofilament proteins.

摘要

在一名52岁男性的默克尔细胞瘤中，通过抗中间丝抗体鉴定出宽度为10纳米的涡状丝。免疫组织化学检测显示，该肿瘤用抗角蛋白抗体以及抗神经丝蛋白68-kd和200-kd亚基的抗体染色，但不用抗150-kd亚基的抗体染色。这是首例报道的表达神经丝蛋白200-kd亚基的默克尔细胞瘤病例。