Uvnäs B, Aborg C H, Lyssarides L
Agents Actions. 1987 Apr;20(3-4):146-8. doi: 10.1007/BF02074653.
Isolated rat peritoneal mast cells released histamine on superfusion with isotonic salt solutions or isotonic deionized sucrose. The histamine release followed the kinetics of cation exchange characteristic of the release from similarly superfused isolated mast cell granules and histamine charged carboxylic resin IRC-50. The histamine release was accompanied by an efflux of potassium and ascribed to an endogenous cation exchange K+ in equilibrium with Hi+ occurring on the passage of outflowing potassium ions over histamine storing granules.
分离的大鼠腹膜肥大细胞在与等渗盐溶液或等渗去离子蔗糖进行灌流时会释放组胺。组胺的释放遵循阳离子交换动力学,这是从类似灌流的分离肥大细胞颗粒和带组胺的羧酸树脂IRC - 50释放时的特征。组胺的释放伴随着钾离子外流,这归因于内源性阳离子交换K⁺与H⁺处于平衡状态,这种平衡在流出的钾离子通过储存组胺的颗粒时发生。