Department of Psychobiology (Departamento de Psicobiologia), Universidade Federal de São Paulo, Brazil.
Curr Neuropharmacol. 2013 Sep;11(5):484-90. doi: 10.2174/1570159X11311050003.
To evaluate and compare the effectiveness of available treatments for cocaine dependence in schizophrenic patients.
We searched articles published between May 2002 and June 2012 in the following databases: Scopus, Pubmed and Web of Knowledge. The key words utilised were "schizophrenia", "dementia praecox", "schizophrenic disorder", "cocaine related disorder", "cocaine abuse", "cocaine addiction", "cocaine dependence", "treatment", "therapeutic", and "drug therapy".
Original articles in English, Portuguese and Spanish were selected. Controlled, double-blind and open-label studies involving only human subjects were included in this review.
We found studies on typical and atypical antipsychotics and one monoamine transporter antagonist. There were few indications of the effectiveness of atypical antipsychotic medications for the treatment of cocaine dependence in patients with schizophrenia.
We suggest that further studies be conducted with atypical antipsychotic medicationsand greater methodological strictness, including using a placebo group in the studies, so that health professionals can determine the real effectiveness of this class of medication for the treatment of cocaine dependence in schizophrenic patients.
评估和比较精神分裂症患者可卡因依赖的现有治疗方法的效果。
我们在以下数据库中搜索了 2002 年 5 月至 2012 年 6 月之间发表的文章：Scopus、Pubmed 和 Web of Knowledge。使用的关键词是“精神分裂症”、“早发性痴呆”、“精神分裂症障碍”、“与可卡因相关的障碍”、“可卡因滥用”、“可卡因成瘾”、“可卡因依赖”、“治疗”、“治疗”和“药物治疗”。
选择英文、葡萄牙文和西班牙文的原始文章。本综述包括仅涉及人类受试者的对照、双盲和开放标签研究。
我们发现了关于典型和非典型抗精神病药物以及一种单胺转运体拮抗剂的研究。非典型抗精神病药物治疗精神分裂症患者可卡因依赖的有效性的证据很少。
我们建议对非典型抗精神病药物进行进一步的研究，并提高方法的严格性，包括在研究中使用安慰剂组，以便卫生专业人员能够确定这类药物治疗精神分裂症患者可卡因依赖的真实效果。
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