人体血浆脂褐素黑色素由色氨酸代谢产物形成。
Human plasma lipofuscin melanins formed from tryptophan metabolites.
作者信息
Hegedus Z L, Frank H A, Altschule M D, Nayak U
出版信息
Arch Int Physiol Biochim. 1986 Dec;94(5):339-48. doi: 10.3109/13813458609071434.
PMID:2440410
Abstract
Incubation of human plasma with the tryptophan metabolites 3-hydroxy-DL-kynurenine (3HK) or 3-hydroxyanthranilic acid (3HAA) yields soluble brown pigments with the fluorescence spectrophotometric and paper chromatographic properties of plasma lipofuscin (PL). An alternative to the recognized tyrosine pathway of melanogenesis is therefore demonstrated in human plasma.
摘要
人血浆与色氨酸代谢产物3-羟基-DL-犬尿氨酸（3HK）或3-羟基邻氨基苯甲酸（3HAA）一起孵育，会产生具有血浆脂褐素（PL）的荧光分光光度法和纸色谱特性的可溶性棕色色素。因此，在人血浆中证明了一种公认的黑色素生成酪氨酸途径的替代途径。
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