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通过治疗高尿酸血症预防肾损伤。

Prevention of renal damage by treating hyperuricemia.

作者信息

Nickavar Azar

机构信息

Department of Pediatric Nephrology, Aliasghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran.

出版信息

Int J Prev Med. 2013 Nov;4(11):1318-20.

PMID:24404368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3883258/
Abstract

Nephrolithiasis, obstructive renal failure, essential hypertension, and chronic tubulointerstitial nephritis have been considered as the renal complications of hyperuricemia. Massive proteinuria has been rarely reported as the primary manifestation of increased serum uric acid. This is the report of a child presented with proteinuira, hypertension, and glomerular scelrosis secondary to hypouricosuric hyperuricemia, who was treated by uric acid lowering management.

摘要

肾结石、梗阻性肾衰竭、原发性高血压和慢性肾小管间质性肾炎被认为是高尿酸血症的肾脏并发症。大量蛋白尿作为血清尿酸升高的主要表现鲜有报道。本文报告一名因低尿酸排泄性高尿酸血症继发蛋白尿、高血压和肾小球硬化的儿童，经降尿酸治疗后康复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82c0/3883258/51a8955f6727/IJPVM-4-1318-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82c0/3883258/e9b7050779c2/IJPVM-4-1318-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82c0/3883258/51a8955f6727/IJPVM-4-1318-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82c0/3883258/e9b7050779c2/IJPVM-4-1318-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82c0/3883258/51a8955f6727/IJPVM-4-1318-g003.jpg

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引用本文的文献

1
Comment on: Prevention of Renal Damage by Treating Hyperuricemia.关于《通过治疗高尿酸血症预防肾损伤》的评论
Int J Prev Med. 2015 Feb 20;6:10. doi: 10.4103/2008-7802.151815. eCollection 2015.

本文引用的文献

1
Hyperuricemia.高尿酸血症。
Can Fam Physician. 1981 Feb;27(2):246-9.
2
Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.Glut9是尿酸盐稳态的主要调节因子，其基因失活会导致高尿酸尿症和尿酸盐肾病。
Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15501-6. doi: 10.1073/pnas.0904411106. Epub 2009 Aug 21.
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Clinical quiz. A patient with hyperuricemia and renal failure.
Pediatr Nephrol. 2007 Jul;22(7):948-53. doi: 10.1007/s00467-007-0457-7. Epub 2007 Mar 24.
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Pharmacological treatment of acute and chronic hyperuricemia in kidney diseased patients.
Contrib Nephrol. 2005;147:149-160. doi: 10.1159/000082552.
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Functional consequences of a novel uromodulin mutation in a family with familial juvenile hyperuricaemic nephropathy.
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