Novel, sulfonamide linked inhibitors of the hepatitis C virus NS3 protease.
作者信息
Kirschberg Thorsten A, Squires Neil H, Yang Huiling, Corsa Amoreena C, Tian Yang, Tirunagari Neeraj, Sheng X Christopher, Kim Choung U
机构信息
Gilead Sciences, Inc., Department of Medicinal Chemistry, 333 Lakeside Dr, Foster City, CA 94404, USA.
Gilead Sciences, Inc., Department of Medicinal Chemistry, 333 Lakeside Dr, Foster City, CA 94404, USA.
出版信息
Bioorg Med Chem Lett. 2014 Feb 1;24(3):969-72. doi: 10.1016/j.bmcl.2013.12.060. Epub 2013 Dec 21.
PMID:24405705
Abstract
A sulfonamide replacement of the P2-P3 amide bond in the context of macrocyclic HCV NS3 protease inhibitors was investigated. These analogs displayed good inhibitory potency in the absence of any P3 capping group. The synthesis and preliminary SAR are described.
摘要
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