卵母细胞的体外成熟并非小鼠后代成年后发生代谢综合征的危险因素。
In vitro maturation of oocytes is not a risk factor for adult metabolic syndrome of mouse offspring.
作者信息
Li Hua, Jia Gui-Hua, Lu Xi-Lan, Zhang Gang, Tian Kai-Yong, Li Jun-Tao, Zhang Jian-Min
机构信息
Department of Obstetrics and Gynecology, Jinan Central Hospital Affiliated to Shandong University, China.
Department of Reproductive Medicine, Jinan Central Hospital Affiliated to Shandong University, China.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2014 Mar;174:96-9. doi: 10.1016/j.ejogrb.2013.12.016. Epub 2013 Dec 17.
OBJECTIVE
To evaluate the effect of in vitro maturation (IVM) of oocytes on the serum cholesterol profile, glucose and insulin tolerance, blood pressure, and heart rate of adult mouse offspring.
STUDY DESIGN
The serum cholesterol profile, glucose and insulin tolerance, blood pressure, and heart rate of adult offspring born from in vitro matured oocytes were compared with those of adult offspring born from in vivo matured oocytes.
RESULTS
Offspring born from in vitro matured oocytes showed a normal serum cholesterol profile. In the glucose tolerance test, glucose levels were consistently elevated in adult offspring born from in vitro matured oocytes compared with those born from in vivo matured oocytes, but the differences did not reach statistical significance. There were no significant differences in insulin tolerance, blood pressure, and heart rate between adult offspring born from in vitro matured oocytes and those from in vivo matured oocytes.
CONCLUSION
No alterations were found in the metabolism profile of adult mouse offspring born from in vitro matured oocytes compared with that from in vivo matured oocytes.
目的
评估卵母细胞体外成熟（IVM）对成年小鼠后代血清胆固醇水平、葡萄糖和胰岛素耐受性、血压及心率的影响。
研究设计
将体外成熟卵母细胞所生成年后代的血清胆固醇水平、葡萄糖和胰岛素耐受性、血压及心率与体内成熟卵母细胞所生成年后代进行比较。
结果
体外成熟卵母细胞所生后代血清胆固醇水平正常。在葡萄糖耐量试验中，与体内成熟卵母细胞所生成年后代相比，体外成熟卵母细胞所生成年后代的血糖水平持续升高，但差异无统计学意义。体外成熟卵母细胞所生成年后代与体内成熟卵母细胞所生成年后代在胰岛素耐受性、血压及心率方面无显著差异。
结论
与体内成熟卵母细胞所生成年小鼠后代相比，体外成熟卵母细胞所生成年小鼠后代的代谢状况未发现改变。
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