Hansz J, Sawiński K
Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114(2):203-11.
The studies described compare the effect of spleen cell suspensions from 11 patients with Hodgkin's disease (HD) and 5 healthy subjects on the clonal growth of autologous marrow granulopoietic progenitors in diffusion chamber culture (CFU-G/D). Adherent monocyte/macrophage fraction of splenocytes from HD suppresses the proliferation of autologous CFU-G/D. This inhibition was mediated by an indomethacin-sensitive humoral factor(s). Non-adherent lymphoid cells stimulated myeloid colony formation. Dose response curves demonstrated a markedly increased inhibitory-activity production already by low numbers of splenic monocytes/macrophages from HD whereas a comparable counts of monocytes/macrophages from the spleens of healthy subjects stimulated the CFU-G/D growth. These results may suggest a possible activation of splenic monocytes/macrophages with an enhanced prostaglandin-mediated suppressor activity release for local granulocytopoiesis in the spleens of patients with HD.
所描述的研究比较了11例霍奇金病（HD）患者和5名健康受试者的脾细胞悬液对扩散室培养（CFU-G/D）中自体骨髓粒细胞生成祖细胞克隆生长的影响。HD患者脾细胞中贴壁单核细胞/巨噬细胞部分抑制自体CFU-G/D的增殖。这种抑制作用由一种对吲哚美辛敏感的体液因子介导。非贴壁淋巴细胞刺激髓系集落形成。剂量反应曲线表明，HD患者少量脾单核细胞/巨噬细胞就能产生明显增强的抑制活性，而健康受试者脾脏中数量相当的单核细胞/巨噬细胞则刺激CFU-G/D生长。这些结果可能提示HD患者脾脏中脾单核细胞/巨噬细胞可能被激活，前列腺素介导的抑制活性释放增强，从而对局部粒细胞生成产生影响。
