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用针对白细胞共同抗原的限制性和非限制性表位的单克隆抗体抑制自然杀伤细胞介导的细胞溶解作用。

Inhibition of natural killer-cell mediated cytolysis with monoclonal antibodies to restricted and non-restricted epitopes of the leucocyte common antigen.

作者信息

Starling G C, Davidson S E, McKenzie J L, Hart D N

出版信息

Immunology. 1987 Jul;61(3):351-6.

PMID:2440797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453401/
Abstract

Three monoclonal antibodies recognizing different epitopes of the leucocyte common molecule, CMRF-11 (against the restricted or B-220 leucocyte common molecule), CMRF-12 and CMRF-26 [each against a different epitope on the non-restricted or T200 leucocyte common (CD45) molecule], were tested for their effects on lymphocyte cytotoxicity. The individual monoclonal antibodies inhibited human natural killer cell-mediated cytolysis (NK-CMC) weakly, but a mixture of CMRF-11 + 12 + 26 antibodies inhibited cytolysis more consistently and to a greater extent. This mixture did not inhibit cytotoxic T lymphocytes derived from secondary mixed lymphocyte cultures. The CMRF-11 + 12 + 26 mix was shown to inhibit a post-conjugate formation stage of lysis at the effector cell level. Inhibition of NK-CMC of a wide range of target cells, including the T-cell lines Jurkat, HSB2 and Molt 4, was demonstrated.

摘要

三种识别白细胞共同分子不同表位的单克隆抗体，即CMRF-11（针对限制性或B-220白细胞共同分子）、CMRF-12和CMRF-26 [每种针对非限制性或T200白细胞共同（CD45）分子上的不同表位]，被检测它们对淋巴细胞细胞毒性的影响。单独的单克隆抗体对人自然杀伤细胞介导的细胞溶解（NK-CMC）有微弱抑制作用，但CMRF-11 + 12 + 26抗体混合物对细胞溶解的抑制作用更稳定且程度更大。该混合物不抑制来自二级混合淋巴细胞培养物的细胞毒性T淋巴细胞。已证明CMRF-11 + 12 + 26混合物在效应细胞水平抑制裂解的共轭后形成阶段。证实了对包括T细胞系Jurkat、HSB2和Molt 4在内的多种靶细胞的NK-CMC有抑制作用。

相似文献

1
Inhibition of natural killer-cell mediated cytolysis with monoclonal antibodies to restricted and non-restricted epitopes of the leucocyte common antigen.用针对白细胞共同抗原的限制性和非限制性表位的单克隆抗体抑制自然杀伤细胞介导的细胞溶解作用。
Immunology. 1987 Jul;61(3):351-6.
2
CD45 molecule cross-linking inhibits natural killer cell-mediated lysis independently of lytic triggering.CD45分子交联可独立于裂解触发而抑制自然杀伤细胞介导的细胞溶解。
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Antibodies to the common leukocyte antigen (T200) inhibit an early phase in the activation of resting human B cells.针对常见白细胞抗原（T200）的抗体可抑制静息人B细胞激活的早期阶段。
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Expression of the CMRF-35 antigen, a new member of the immunoglobulin gene superfamily, is differentially regulated on leucocytes.免疫球蛋白基因超家族的新成员CMRF - 35抗原在白细胞上的表达受到差异调节。
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本文引用的文献

1
Studies on the mechanism of NK cell lysis.自然杀伤细胞裂解机制的研究。
J Immunol. 1982 Apr;128(4):1786-91.
2
Definition of a "trigger" stage in the NK cytolytic reaction sequence by a monoclonal antibody to the glycoprotein T-200.用针对糖蛋白T - 200的单克隆抗体对自然杀伤细胞溶细胞反应序列中“触发”阶段的定义。
J Immunol. 1983 Sep;131(3):1149-53.
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Surface antigens on mouse natural killer cells: use of monoclonal antibodies to inhibit or to enrich cytotoxic activity.小鼠自然杀伤细胞上的表面抗原：利用单克隆抗体抑制或富集细胞毒性活性。
J Immunol. 1981 Sep;127(3):982-6.
4
Major histocompatibility complex antigens in rat kidney, ureter, and bladder. Localization with monoclonal antibodies and demonstration of Ia-positive dendritic cells.大鼠肾脏、输尿管和膀胱中的主要组织相容性复合体抗原。用单克隆抗体定位及Ia阳性树突状细胞的证实。
Transplantation. 1981 May;31(5):318-25. doi: 10.1097/00007890-198105010-00003.
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A function for human T200 in natural killer cytolysis.人T200在自然杀伤细胞溶解中的作用。
Transplantation. 1983 Aug;36(2):166-71. doi: 10.1097/00007890-198308000-00011.
6
High molecular weight lymphocyte surface proteins are structurally related and are expressed on different cell populations at different times during lymphocyte maturation and differentiation.高分子量淋巴细胞表面蛋白在结构上相关，且在淋巴细胞成熟和分化过程中的不同时间表达于不同细胞群体。
J Immunol. 1982 Apr;128(4):1676-84.
7
A novel antigenic cell surface protein associated with T200 is involved in the post-activation stage of human NK cell-mediated lysis.
J Immunol. 1984 Sep;133(3):1391-6.
8
NK and T cell subsets regulate antibody production by human in vivo antigen-induced lymphoblastoid B cells.自然杀伤细胞和T细胞亚群可调节人体内由抗原诱导的淋巴母细胞样B细胞产生抗体的过程。
J Immunol. 1984 Feb;132(2):611-5.
9
Blockade of NK cell lysis is a property of monoclonal antibodies that bind to distinct regions of T-200.自然杀伤细胞（NK细胞）溶解作用的阻断是单克隆抗体的一种特性，这些单克隆抗体可与T-200的不同区域结合。
J Immunol. 1983 Oct;131(4):1742-7.
10
Studies on the mechanism of natural killer cytotoxicity. III. Activation of NK cells by interferon augments the lytic activity of released natural killer cytotoxic factors (NKCF).自然杀伤细胞细胞毒性机制的研究。III. 干扰素对自然杀伤细胞的激活增强了释放的自然杀伤细胞细胞毒性因子（NKCF）的裂解活性。
J Immunol. 1983 Jun;130(6):2960-4.