Sarmiento M, Loken M R, Trowbridge I S, Coffman R L, Fitch F W
J Immunol. 1982 Apr;128(4):1676-84.
HMW lymphocyte surface proteins T20 and B220, which are expressed on T and B cells, respectively, have been found to be extensively related in structure, beyond what would be expected by the sharing of the determinant detected by monoclonal antibody 13/2. In addition, another HMW protein (T200A) has been discovered, which is preferentially expression proliferating T cells, and which exhibits significant structural homology with T200, but does not express the 13/2 determinant. T200A bears a novel antigenic determinant, detected by monoclonal antibody BS-S28E, which is not shared by either T200 or B220. A fourth HMW protein (170/100) has been found, which is expressed on most lymphocytes, but which is neither structurally nor antigenically related to T200A, T200, or B220. Monoclonal antibodies reactive with 170/100 inhibit T cell-mediated cytolysis, although monoclonal antibodies reactive with T200A, T200, or B220 do not.
高分子量淋巴细胞表面蛋白T20和B220分别在T细胞和B细胞上表达，已发现它们在结构上广泛相关，超出了单克隆抗体13/2所检测到的决定簇共享所预期的范围。此外，还发现了另一种高分子量蛋白（T200A），它优先表达于增殖的T细胞，与T200表现出显著的结构同源性，但不表达13/2决定簇。T200A带有一种新的抗原决定簇，可被单克隆抗体BS-S28E检测到，T200或B220均不具有该决定簇。已发现第四种高分子量蛋白（170/100），它在大多数淋巴细胞上表达，但在结构和抗原性上均与T200A、T200或B220无关。与170/100反应的单克隆抗体可抑制T细胞介导的细胞溶解，而与T200A、T200或B220反应的单克隆抗体则不能。
