Suppr超能文献

在有丝分裂中标记靶基因:表型转录因子和癌基因的共同表观遗传特征?

Bookmarking target genes in mitosis: a shared epigenetic trait of phenotypic transcription factors and oncogenes?

机构信息

Authors' Affiliations: Vermont Cancer Center, College of Medicine; Department of Biochemistry, University of Vermont, Burlington, Vermont; Center for Biomedical Research; FONDAP Center for Genome Regulation, Universidad Andres Bello, Santiago, Chile; Departments of Orthopedic Surgery and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.

出版信息

Cancer Res. 2014 Jan 15;74(2):420-5. doi: 10.1158/0008-5472.CAN-13-2837. Epub 2014 Jan 9.

Abstract

The regulatory information for phenotype, proliferation, and growth of normal and tumor cells must be maintained through genome replication in the S phase and cell division during mitosis. Epigenetic mechanisms that include DNA methylation, posttranslational modifications of histones, selective utilization of histone variants, and inheritable RNA molecules play pivotal roles in maintaining cellular identity through mitotic divisions. Recent studies demonstrate that mitotic occupancy of genes, which are determinants of cell fate, growth, and proliferation, by lineage-restricted transcription factors is a key epigenetic mechanism for retention and transmission of cellular expression memory. Evidence is emerging for the presence of distinct transcriptional regulatory microenvironments in mitotic chromosomes in which the genes bookmarked for reactivation postmitotically reside. Importantly, some oncoproteins are present in mitotic microenvironments where they occupy target genes during mitosis and may contribute to perpetuating the transformed phenotype. We discuss emerging regulatory implications of epigenetically bookmarking genes during mitosis for physiologic control as well as for the onset and progression of cancer.

摘要

维持正常和肿瘤细胞表型、增殖和生长的调控信息必须通过 S 期的基因组复制和有丝分裂期间的细胞分裂来实现。包括 DNA 甲基化、组蛋白的翻译后修饰、组蛋白变体的选择性利用以及可遗传的 RNA 分子在内的表观遗传机制,在有丝分裂分裂过程中对维持细胞身份起着关键作用。最近的研究表明,谱系限制转录因子对决定细胞命运、生长和增殖的基因在有丝分裂中的占据,是保留和传递细胞表达记忆的关键表观遗传机制。有证据表明,在有丝分裂染色体中存在着不同的转录调控微环境,其中标记为有丝分裂后重新激活的基因存在于这些微环境中。重要的是,一些癌蛋白存在于有丝分裂微环境中,它们在有丝分裂期间占据靶基因,并可能有助于维持转化表型。我们讨论了有丝分裂过程中表观遗传标记基因的新兴调控意义,这些意义既涉及生理控制,也涉及癌症的发生和进展。

相似文献

1
Bookmarking target genes in mitosis: a shared epigenetic trait of phenotypic transcription factors and oncogenes?
Cancer Res. 2014 Jan 15;74(2):420-5. doi: 10.1158/0008-5472.CAN-13-2837. Epub 2014 Jan 9.
2
Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Phenotypes.
Mol Cancer Res. 2018 Nov;16(11):1617-1624. doi: 10.1158/1541-7786.MCR-18-0415. Epub 2018 Jul 12.
3
Mitotic bookmarking of genes: a novel dimension to epigenetic control.
Nat Rev Genet. 2010 Aug;11(8):583-9. doi: 10.1038/nrg2827. Epub 2010 Jul 13.
4
Architectural epigenetics: mitotic retention of mammalian transcriptional regulatory information.
Mol Cell Biol. 2010 Oct;30(20):4758-66. doi: 10.1128/MCB.00646-10. Epub 2010 Aug 9.
5
Mitotic bookmarking in development and stem cells.
Development. 2017 Oct 15;144(20):3633-3645. doi: 10.1242/dev.146522.
6
Bookmarking the genome: maintenance of epigenetic information.
J Biol Chem. 2011 May 27;286(21):18355-61. doi: 10.1074/jbc.R110.197061. Epub 2011 Mar 24.
8
Transcription factor retention on mitotic chromosomes: regulatory mechanisms and impact on cell fate decisions.
FEBS Lett. 2018 Mar;592(6):878-887. doi: 10.1002/1873-3468.12828. Epub 2017 Sep 12.
9
Transcription-factor-mediated epigenetic control of cell fate and lineage commitment.
Biochem Cell Biol. 2009 Feb;87(1):1-6. doi: 10.1139/O08-094.
10
Widespread Mitotic Bookmarking by Histone Marks and Transcription Factors in Pluripotent Stem Cells.
Cell Rep. 2017 May 16;19(7):1283-1293. doi: 10.1016/j.celrep.2017.04.067.

引用本文的文献

2
Higher order genomic organization and epigenetic control maintain cellular identity and prevent breast cancer.
Genes Chromosomes Cancer. 2019 Jul;58(7):484-499. doi: 10.1002/gcc.22731. Epub 2019 Mar 15.
3
4
Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Phenotypes.
Mol Cancer Res. 2018 Nov;16(11):1617-1624. doi: 10.1158/1541-7786.MCR-18-0415. Epub 2018 Jul 12.
5
Nuclear organization mediates cancer-compromised genetic and epigenetic control.
Adv Biol Regul. 2018 Aug;69:1-10. doi: 10.1016/j.jbior.2018.05.001. Epub 2018 May 9.
6
Higher order genomic organization and regulatory compartmentalization for cell cycle control at the G1/S-phase transition.
J Cell Physiol. 2018 Oct;233(10):6406-6413. doi: 10.1002/jcp.26741. Epub 2018 May 10.
8
A role for mitotic bookmarking of SOX2 in pluripotency and differentiation.
Genes Dev. 2016 Nov 15;30(22):2538-2550. doi: 10.1101/gad.289256.116. Epub 2016 Dec 5.
9
The loading of condensin in the context of chromatin.
Curr Genet. 2017 Aug;63(4):577-589. doi: 10.1007/s00294-016-0669-0. Epub 2016 Dec 1.
10
Chromatin proteins and RNA are associated with DNA during all phases of mitosis.
Cell Discov. 2016 Oct 25;2:16038. doi: 10.1038/celldisc.2016.38. eCollection 2016.

本文引用的文献

2
Mitotic bookmarking by transcription factors.
Epigenetics Chromatin. 2013 Apr 2;6(1):6. doi: 10.1186/1756-8935-6-6.
3
Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes.
Genes Dev. 2013 Feb 1;27(3):251-60. doi: 10.1101/gad.206458.112. Epub 2013 Jan 25.
4
Histone modifications and mitosis: countermarks, landmarks, and bookmarks.
Trends Cell Biol. 2013 Apr;23(4):175-84. doi: 10.1016/j.tcb.2012.11.005. Epub 2012 Dec 13.
5
Tissue-specific mitotic bookmarking by hematopoietic transcription factor GATA1.
Cell. 2012 Aug 17;150(4):725-37. doi: 10.1016/j.cell.2012.06.038.
6
A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation.
J Cell Sci. 2012 Jun 1;125(Pt 11):2732-9. doi: 10.1242/jcs.100909. Epub 2012 Mar 5.
7
Asymmetric cell division: a persistent issue?
Dev Cell. 2012 Feb 14;22(2):235-6. doi: 10.1016/j.devcel.2012.01.016.
8
Cellular epigenetic stability and cancer.
Trends Genet. 2012 Mar;28(3):118-27. doi: 10.1016/j.tig.2011.11.005. Epub 2012 Jan 5.
9
Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation.
Nat Cell Biol. 2011 Oct 9;13(11):1295-304. doi: 10.1038/ncb2341.
10
New insight into the mitotic chromosome structure: irregular folding of nucleosome fibers without 30-nm chromatin structure.
Cold Spring Harb Symp Quant Biol. 2010;75:439-44. doi: 10.1101/sqb.2010.75.034. Epub 2011 Mar 29.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验