Zaidi Sayyed K, Lian Jane B, van Wijnen Andre, Stein Janet L, Stein Gary S
Department of Biochemistry and University of Vermont Cancer Center, The Larner College of Medicine, University of Vermont, 89 Beaumont Avenue, Burlington, VT, 05405, USA.
Departments of Orthopedic Surgery & Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Adv Exp Med Biol. 2017;962:95-102. doi: 10.1007/978-981-10-3233-2_7.
Epigenetic control of gene expression contributes to dynamic responsiveness of cellular processes that include cell cycle, cell growth and differentiation. Mitotic gene bookmarking, retention of sequence-specific transcription factors at target gene loci, including the RUNX regulatory proteins, provide a novel dimension to epigenetic regulation that sustains cellular identity in progeny cells following cell division. Runx transcription factor retention during mitosis coordinates physiological control of cell growth and differentiation in a broad spectrum of biological conditions, and is associated with compromised gene expression in pathologies that include cancer.
基因表达的表观遗传调控有助于细胞过程的动态响应，这些细胞过程包括细胞周期、细胞生长和分化。有丝分裂基因标记，即序列特异性转录因子在靶基因位点的保留，包括RUNX调节蛋白，为表观遗传调控提供了一个新的维度，在细胞分裂后维持子代细胞中的细胞特性。有丝分裂期间Runx转录因子的保留在广泛的生物学条件下协调细胞生长和分化的生理控制，并且与包括癌症在内的病理学中受损的基因表达相关。
