TNF-α-308 多态性与消化系统癌症风险的关系：荟萃分析。
TNF-α-308 polymorphism and risk of digestive system cancers: a meta-analysis.
机构信息
Xu-Feng Guo, Jun Wang, Shi-Jie Yu, Jia Song, Meng-Yao Ji, Zhuo Cao, Ji-Xiang Zhang, Jing Wang, Wei-Guo Dong, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.
出版信息
World J Gastroenterol. 2013 Dec 28;19(48):9461-71. doi: 10.3748/wjg.v19.i48.9461.
AIM
To evaluate the association between the tumour necrosis factor alpha-308 (TNF-α-308) gene polymorphism and the risk of digestive system cancers.
METHODS
All eligible case-control studies published up to December 2012 were identified by searching PubMed, Web of Science, Embase and China National Knowledge Internet without language restrictions. The risk of digestive system cancers associated with the TNF-α-308 polymorphism was estimated for each study using odds ratio (OR) together with its 95%CI, respectively. Cochrane Collaboration RevMan 5.1 was used to perform the analysis. A χ²-test-based Q statistic test and an I² test were performed to assess the between-study heterogeneity. When the Q test was significant (P < 0.05) or I² > 50%, the random effects model was used, otherwise the fixed effects model was used.
RESULTS
Fifty-eight studies from fifty-five publications with a total of 9986 cancer patients and 15511 healthy controls were included. Overall, a significant association was found between the TNF-α-308 polymorphism and the risk of digestive system cancers [dominant model: OR = 1.23, 95%CI: 1.09-1.39, (G/A) vs (G/G): OR = 1.15, 95%CI: 1.02-1.28, (A/A) vs (G/G): OR = 1.44, 95%CI: 1.19-1.73, recessive model: OR = 1.38, 95%CI: 1.15-1.66]. Furthermore, when the analysis was stratified by ethnicity, similar results were observed in both the Asian and Caucasian populations, except for the dominant model and heterozygote comparisons in the Asian population [dominant model: OR = 1.24, 95%CI: 0.99-1.56, (G/A) vs (G/G): OR = 1.09, 95%CI: 0.96-1.24]. When the cancer type subgroups were examined, similar results were detected in gastric and hepatocellular carcinomas; however, no significant association was observed among other digestive system cancers.
CONCLUSION
The TNF-α-308 gene polymorphism may be significantly associated with the risk of gastric and hepatocellular carcinomas, but not colorectal, pancreatic, or oesophageal cancer, in the Asian population.
目的
评估肿瘤坏死因子-α-308（TNF-α-308）基因多态性与消化系统癌症风险之间的关联。
方法
通过检索 PubMed、Web of Science、Embase 和中国国家知识基础设施，无语言限制，检索截至 2012 年 12 月发表的所有合格的病例对照研究。分别使用优势比（OR）及其 95%置信区间（CI）评估每个研究中 TNF-α-308 多态性与消化系统癌症风险的关联。使用 Cochrane 协作 RevMan 5.1 进行分析。使用基于 χ²检验的 Q 统计量检验和 I²检验评估研究间异质性。当 Q 检验显著（P<0.05）或 I²>50%时，使用随机效应模型，否则使用固定效应模型。
结果
共有 55 篇文献的 58 项研究，包括 9986 例癌症患者和 15511 例健康对照者。总体而言，TNF-α-308 多态性与消化系统癌症风险之间存在显著关联[显性模型：OR=1.23，95%CI：1.09-1.39，（G/A）与（G/G）相比：OR=1.15，95%CI：1.02-1.28，（A/A）与（G/G）相比：OR=1.44，95%CI：1.19-1.73，隐性模型：OR=1.38，95%CI：1.15-1.66]。此外，按种族分层分析时，在亚洲和高加索人群中均观察到类似结果，除了亚洲人群中的显性模型和杂合子比较[显性模型：OR=1.24，95%CI：0.99-1.56，（G/A）与（G/G）相比：OR=1.09，95%CI：0.96-1.24]。当检查癌症类型亚组时，在胃癌和肝细胞癌中观察到类似结果；然而，在其他消化系统癌症中未观察到显著关联。
结论
TNF-α-308 基因多态性可能与亚洲人群的胃癌和肝细胞癌风险显著相关，但与结直肠癌、胰腺癌或食管癌无关。
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