Desmedt D H, Egrise D, Mendlewicz J
J Affect Disord. 1987 May-Jun;12(3):193-8. doi: 10.1016/0165-0327(87)90026-7.
We have investigated platelet [3H]imipramine binding in normal controls and patients with primary endogenous depression (unipolar and bipolar) or schizophrenia. Absolute Bmax values did not differ between subgroups. However, when circannual variation of binding was taken into account by expressing results as percentages of normalised values derived from the multiple linear regression of Bmax values as a function of time of sampling, schizophrenic patients were found to have higher Bmax than normal controls. There was no significant difference between depressed patients and controls, nor between patients exhibiting plasma cortisol suppression and non-suppression after the dexamethasone suppression test. A significant negative correlation was found between relative Bmax values and cerebrospinal 5-HIAA levels in depressed patients.
我们研究了正常对照组以及原发性内源性抑郁症（单相和双相）或精神分裂症患者血小板的[3H]丙咪嗪结合情况。各亚组之间的绝对最大结合容量（Bmax）值没有差异。然而，当通过将结果表示为Bmax值作为采样时间函数的多元线性回归得出的标准化值的百分比来考虑结合的年度变化时，发现精神分裂症患者的Bmax高于正常对照组。抑郁症患者与对照组之间、地塞米松抑制试验后血浆皮质醇有抑制和无抑制表现的患者之间均无显著差异。在抑郁症患者中，相对Bmax值与脑脊液5-羟吲哚乙酸（5-HIAA）水平之间存在显著负相关。
