Rehavi M, Weizman R, Carel C, Apter A, Tyano S
Psychiatry Res. 1984 Sep;13(1):31-9. doi: 10.1016/0165-1781(84)90116-1.
High-affinity 3H-imipramine binding to platelet membranes was evaluated in 12 untreated children and adolescents aged 11-17 years who met the DSM-III criteria for major affective disorders. The affective patients were compared to 13 nonaffective subjects and 15 normal controls of similar ages. No significant difference in the maximal binding of 3H-imipramine (Bmax) and Kd values could be found among the three groups. 3H-Imipramine binding values failed to discriminate between patients with major depression and those with bipolar disorder, depressed type. No association between a positive family history of major affective disorders and 3H-imipramine binding values was detected.
在12名符合《精神疾病诊断与统计手册》第三版（DSM-III）中重度情感障碍标准、年龄在11至17岁的未接受治疗的儿童及青少年中，评估了高亲和力3H-丙咪嗪与血小板膜的结合情况。将情感障碍患者与13名非情感障碍受试者以及15名年龄相仿的正常对照进行比较。三组之间在3H-丙咪嗪的最大结合量（Bmax）和解离常数（Kd）值上未发现显著差异。3H-丙咪嗪结合值无法区分重度抑郁症患者和双相情感障碍抑郁型患者。未检测到重度情感障碍的阳性家族史与3H-丙咪嗪结合值之间存在关联。
