葡萄膜炎患者使用结核感染T细胞检测（QuantiFERON-TB gold）三年的经验。
Three years of experience with QuantiFERON-TB gold testing in patients with uveitis.
作者信息
Jakob E, Max R, Zimmermann S, Dalpke A H, Alle W, Becker M, Mackensen F
机构信息
University Eye Hospital, Interdisciplinary Uveitis Center , Im Neuenheimer Feld 400, Heidelberg , Germany .
出版信息
Ocul Immunol Inflamm. 2014 Dec;22(6):478-84. doi: 10.3109/09273948.2013.866255. Epub 2014 Jan 10.
PURPOSE
Overview of the results of QuantiFERON-TB Gold (QFT) testing on uveitis patients in an interdisciplinary setting for a period of 3 years.
METHODS
Database search of all the patients tested for tuberculosis (Tb) with QFT.
RESULTS
Of 343 tested patients, overall 80 (23.3%) were positive and 253 (73.8%) negative (results were nonconclusive for 10 patients). Anatomic localization of the patients who tested positive were distributed (% of QFT(+) tests) as anterior n = 12 (15.0%), intermediate n = 22 (27.5%), posterior n = 26 (32.5%), and pan n = 18 (22.5%). In 43 QFT(+) patients we presumed a diagnosis of Tb due to additional clinical findings. Of these patients 16 were treated with full therapy following WHO recommendations.
CONCLUSIONS
QFT testing gives surprisingly high numbers of positives in uveitis patients. This is not sufficiently explained by immigrant status of the patients. The frequency of positives is substantially higher than in other cohorts. This raises important questions regarding treatment implications.
目的
概述在跨学科环境中对葡萄膜炎患者进行3年的结核感染T细胞检测（QFT）的结果。
方法
对所有接受QFT结核病检测的患者进行数据库检索。
结果
在343例接受检测的患者中，总体上80例（23.3%）呈阳性，253例（73.8%）呈阴性（10例结果不确定）。检测呈阳性患者的解剖学定位分布（QFT阳性检测的百分比）为前部n = 12例（15.0%），中间部n = 22例（27.5%），后部n = 26例（32.5%），全葡萄膜炎n = 18例（22.5%）。在43例QFT阳性患者中，由于其他临床发现，我们推测为结核病诊断。其中16例患者按照世界卫生组织的建议接受了全程治疗。
结论
QFT检测在葡萄膜炎患者中呈阳性的数量惊人。患者的移民身份并不能充分解释这一现象。阳性频率明显高于其他队列。这就治疗影响提出了重要问题。
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