Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361102, China.
Mol Neurodegener. 2014 Jan 11;9:6. doi: 10.1186/1750-1326-9-6.
The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer's disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic through the secretory pathway in a highly regulated fashion. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering Aβ generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD.
β-淀粉样蛋白(Aβ)肽被认为是阿尔茨海默病(AD)发病机制中的关键决定因素。Aβ 通过β-和γ-分泌酶对β-淀粉样前体蛋白(APP)的顺序切割产生。APP 和相关的分泌酶是跨膜蛋白,以高度调控的方式通过分泌途径运输。它们的细胞内运输受到干扰可能会影响这些蛋白质之间的动态相互作用,从而改变 Aβ 的产生并加速疾病的发病机制。在此,我们综述了阐明 AD 中这些必需蛋白质成分的细胞内运输调节的最新进展。