Liu Xiaoling, Liu Yan, Ji Shangrong
Key Laboratory of Cell Activities and Stress Adaptations, Ministry of Education, School of Life Sciences, Lanzhou University, South Tianshui Road, Lanzhou 730030, China.
Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, School of Basic Medical Sciences, Xi'an Jiaotong University, West Yanta Road, Xi'an 710061, China.
Membranes (Basel). 2021 Dec 15;11(12):983. doi: 10.3390/membranes11120983.
Alzheimer's disease (AD) is a common neurodegenerative disease whose prevalence increases with age. An increasing number of findings suggest that abnormalities in the metabolism of amyloid precursor protein (APP), a single transmembrane aspartic protein that is cleaved by β- and γ-secretases to produce β-amyloid protein (Aβ), are a major pathological feature of AD. In recent years, a large number of studies have been conducted on the APP processing pathways and the role of secretion. This paper provides a summary of the involvement of secretases in the processing of APP and the potential drug targets that could provide new directions for AD therapy.
阿尔茨海默病（AD）是一种常见的神经退行性疾病，其患病率随年龄增长而增加。越来越多的研究结果表明，淀粉样前体蛋白（APP）代谢异常是AD的主要病理特征，APP是一种单跨膜天冬氨酸蛋白，被β-和γ-分泌酶切割后产生β-淀粉样蛋白（Aβ）。近年来，针对APP加工途径及其分泌作用开展了大量研究。本文综述了分泌酶在APP加工过程中的作用以及可能为AD治疗提供新方向的潜在药物靶点。
