Nishiguchi Y, Kamino K, Sakazaki S, Hashimoto H, Sowa M, Umeyama K, Mitsuhashi T
Gan No Rinsho. 1987 Jun;33(7):841-7.
A case of a duodenal carcinoid which was producing somatostatin, serotonin and ACTH in a 65-year-old man is reported. The patient was found to have a submucosal protruded mass of the duodenal bulb and a tumor mass-like IIa + IIc in the antral portion of the stomach. Subtotal gastrectomy was performed and the histological diagnosis of the tumors were found to be a classical carcinoid of the duodenum and a well-differentiated tubular adenocarcinoma of the stomach. The carcinoid cells of the duodenum had numerous cyto-plasmic granules which were positive by Grimelius staining and negative by Hellerström-Hellmann staining, and 200-300 nm in size, electronmicroscopically. These cells were shown to contain somatostatin, serotonin or ACTH-positive cells by means of monoclonal immunohistochemistry, however, results were negative for gastrin, insulin, glucagon, calcitonin, VIP or PP.
报告了一例65岁男性十二指肠类癌，该类癌产生生长抑素、血清素和促肾上腺皮质激素。患者被发现十二指肠球部有黏膜下突出肿块，胃窦部有肿瘤样IIa + IIc病变。实施了胃次全切除术，肿瘤的组织学诊断为十二指肠经典类癌和胃高分化管状腺癌。十二指肠类癌细胞有许多细胞质颗粒，Grimelius染色呈阳性，Hellerström-Hellmann染色呈阴性，电镜下大小为200 - 300纳米。通过单克隆免疫组织化学方法显示这些细胞含有生长抑素、血清素或促肾上腺皮质激素阳性细胞，然而，胃泌素、胰岛素、胰高血糖素、降钙素、血管活性肠肽或胰多肽检测结果为阴性。
