Gan Jing, Zhou Mingzhu, Chen Wei, Liu Zhenguo
Department of Neurology, Xinhua Hospital Shanghai JiaoTong University, School of Medicine, 1665 Kongjiang Road, Shanghai 20092, China.
Department of Neurology, Xinhua Hospital Shanghai JiaoTong University, School of Medicine, 1665 Kongjiang Road, Shanghai 20092, China.
J Clin Neurosci. 2014 May;21(5):751-4. doi: 10.1016/j.jocn.2013.07.015. Epub 2013 Sep 11.
This study was designed to survey the prevalence and distribution of non-motor symptoms (NMS) in Parkinson's disease (PD) patients in Shanghai, China, and to investigate the association between NMS and health-related quality of life (HRQoL). One hundred fifty-five PD patients were evaluated using the NMS Questionnaire 30 (NMSQuest), Unified Parkinson's Disease Rating Scale (UPDRS) and Parkinson's Disease Questionnaire-39 (PDQ-39). These data were compared with an international cross-sectional study, and the associations of motor and non-motor measures with HRQoL were estimated. Predictors of HRQoL were sought through multiple linear regression analyses. Each PD patient had eight different individual NMS on average. The problems of memory (65.82%), constipation (64.56%) and nocturia (61.39%) were the most frequent complaints. NMS prevalence in PD patients in Shanghai was consistent with that in the international study, although the composition proportions were different. There was a significant association of PDQ-39 score with NMSQuest score (rs=0.433, p=0.000), UPDRS III score (rs=0.473, p=0.000), Hoehn and Yahr (H-Y) stage (rs=0.567, p=0.000), disease duration (rs=0.220, p=0.005), and levodopa equivalent dosage (rs=0.263, p=0.001). H-Y stage (disease severity) and NMS score were the strongest predictors for PDQ-39 score. This study confirmed that NMS are common in PD, occurring across all disease stages and have a great impact on quality of life. NMS progression contributes significantly to HRQoL decline, and should be well recognized and treated.
本研究旨在调查中国上海帕金森病（PD）患者非运动症状（NMS）的患病率及分布情况，并探讨NMS与健康相关生活质量（HRQoL）之间的关联。采用非运动症状问卷30（NMSQuest）、统一帕金森病评定量表（UPDRS）和帕金森病问卷-39（PDQ-39）对155例PD患者进行评估。将这些数据与一项国际横断面研究进行比较，并评估运动和非运动指标与HRQoL的关联。通过多元线性回归分析寻找HRQoL的预测因素。每位PD患者平均有8种不同的个体NMS。记忆问题（65.82%）、便秘（64.56%）和夜尿症（61.39%）是最常见的主诉。上海PD患者的NMS患病率与国际研究一致，尽管构成比例不同。PDQ-39评分与NMSQuest评分（rs=0.433，p=0.000）、UPDRS III评分（rs=0.473，p=0.000）、Hoehn和Yahr（H-Y）分期（rs=0.567，p=0.000）、病程（rs=0.220，p=0.005）以及左旋多巴等效剂量（rs=0.263，p=0.001）之间存在显著关联。H-Y分期（疾病严重程度）和NMS评分是PDQ-39评分的最强预测因素。本研究证实，NMS在PD中很常见，在所有疾病阶段均会出现，并且对生活质量有很大影响。NMS的进展对HRQoL下降有显著影响，应得到充分认识和治疗。
