Department of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China; Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, China.
Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, China; Department of Biophysics, China Medical University, Shenyang 110001, China.
Mater Sci Eng C Mater Biol Appl. 2014 Feb 1;35:1-7. doi: 10.1016/j.msec.2013.10.020. Epub 2013 Oct 31.
The in vitro biodegradation behavior of Mg17Al12 as a second phase in Mg-Al-Zn alloys was investigated via electrochemical measurement and immersion test. The Hank's solutions with neutral and acidic pH values were adopted as electrolytes to simulate the in vivo environment during normal and inflammatory response process. Furthermore, the local orbital density functional theory approach was employed to study the thermodynamical stability of Mg17Al12 phase. All the results proved the occurrence of pitting corrosion process with crackings for Mg17Al12 phase in Hank's solution, but with a much lower degradation rate compared with both AZ31 alloy and pure magnesium. Furthermore, a preliminary explanation on the biodegradation behaviors of Mg17Al12 phase was proposed.
通过电化学测量和浸泡试验研究了 Mg-Al-Zn 合金中第二相 Mg17Al12 的体外生物降解行为。采用中性和酸性 pH 值的 Hank's 溶液作为电解质模拟正常和炎症反应过程中的体内环境。此外，还采用局域轨道密度泛函理论方法研究了 Mg17Al12 相的热力学稳定性。所有结果均证明在 Hank's 溶液中，Mg17Al12 相发生了点蚀腐蚀过程并伴有裂纹，但与 AZ31 合金和纯镁相比，其降解速率要低得多。此外，还对 Mg17Al12 相的生物降解行为提出了初步解释。
